HAMAP rule MF_01422
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01422 |
| Accession | MF_01422 |
| Dates | 28-FEB-2005 (Created)
01-JUN-2023 (Last updated, Version 20) |
| Name | MdtA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76397; [ Recover all ] |
| Triggered by |
HAMAP; MF_01422 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MDTA |
| Protein name | RecName: Full=Multidrug resistance protein MdtA; AltName: Full=Multidrug transporter MdtA; Flags: Precursor; |
| Gene name | Name=mdtA; |
Comments
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| case <OC:Escherichia> | |
| FUNCTION | The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. |
| end case | |
| SUBUNIT | Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| case <OC:Escherichia> | |
| INDUCTION | The mdtABC operon is transcriptionally activated by BaeR. |
| end case | |
| SIMILARITY | Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. |
Keywords
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Gene Ontology
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| GO:0022857; Molecular function:transmembrane transporter activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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Additional information
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| Size range | 401-444 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The sequence of Shigella flexneri is shorter but it is impossible to correct the sequence. |