HAMAP rule MF_01423
General rule information
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Accession | MF_01423 |
Dates | 2-FEB-2005 (Created) 19-NOV-2019 (Last updated, Version 22) |
Name | MdtB |
Scope | Bacteria; Enterobacterales |
Template | P76398 (MDTB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Escherichia>
Function | The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. |
end case
Subunit | Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
case <OC:Escherichia>
Induction | The mdtABC operon is transcriptionally activated by BaeR. |
end case
Similarity | Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. |
Keywords
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Gene Ontology
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GO:0022857; Molecular function: transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 11-12; trigger=yes; |
Additional information
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Size range | 1039-1056 amino acids |
Related rules | None |
Fusion | None |
Comments | The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct. |