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HAMAP rule MF_01423

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General rule information [?]

Accession MF_01423
Dates 2-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 22)
Name MdtB
Scope(s) Bacteria
Template(s) P76398 (MDTB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01423 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDTB
Protein name RecName: Full=Multidrug resistance protein MdtB;
AltName: Full=Multidrug transporter MdtB;
Gene name Name=mdtB;

Comments [?]

case <OC:Escherichia>
FUNCTIONThe MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
end case
SUBUNITPart of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
case <OC:Escherichia>
INDUCTIONThe mdtABC operon is transcriptionally activated by BaeR.
end case
SIMILARITYBelongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0022857; Molecular function:transmembrane transporter activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00873; ACR_tran; 1;
General Transmembrane; -; 11-12;

Features [?]

Additional information [?]

Size range 1039-1056 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct.

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