HAMAP rule MF_01423

General rule information [?]

Accession	MF_01423
Dates	2-FEB-2005 (Created) 19-NOV-2019 (Last updated, Version 22)

Name

MdtB

Scope

Bacteria; Enterobacterales

Template

P76398 (MDTB_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MDTB

Protein name

RecName:		Full=Multidrug resistance protein MdtB;
AltName:		Full=Multidrug transporter MdtB;

Gene name

mdtB

Comments [?]

case <OC:Escherichia>

Function

The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.

end case

Subunit	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.

case <OC:Escherichia>

Induction

The mdtABC operon is transcriptionally activated by BaeR.

end case

Similarity

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0022857; Molecular function: transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF00873; ACR_tran; 1;
PRINTS	PR00702; ACRIFLAVINRP; 1;

Computed features [?]

General

Transmembrane; -; 11-12; trigger=yes;

Additional information [?]

Size range	1039-1056 amino acids
Related rules	None
Fusion	None
Comments	The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct.