HAMAP logo

HAMAP rule MF_01423

Send feedback

General rule information [?]

Accession MF_01423
Dates 2-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 22)
Name MdtB
Bacteria; Enterobacterales
Template P76398 (MDTB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Multidrug resistance protein MdtB;
AltName: Full=Multidrug transporter MdtB;
Gene name

Comments [?]

case <OC:Escherichia>
Function The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
end case
Subunit Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
case <OC:Escherichia>
Induction The mdtABC operon is transcriptionally activated by BaeR.
end case
Similarity Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0022857; Molecular function: transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00873; ACR_tran; 1;

Computed features [?]

General Transmembrane; -; 11-12; trigger=yes;

Additional information [?]

Size range 1039-1056 amino acids
Related rules None
Fusion None
Comments The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct.