HAMAP rule MF_01423
General rule information
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Accession | MF_01423 |
Dates | 2-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 22) |
Name | MdtB |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P76398 (MDTB_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01423 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MDTB |
Protein name | RecName: Full=Multidrug resistance protein MdtB; AltName: Full=Multidrug transporter MdtB; |
Gene name | Name=mdtB; |
Comments
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case <OC:Escherichia> | |
FUNCTION | The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. |
end case | |
SUBUNIT | Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
case <OC:Escherichia> | |
INDUCTION | The mdtABC operon is transcriptionally activated by BaeR. |
end case | |
SIMILARITY | Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. |
Keywords
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Gene Ontology
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GO:0022857; Molecular function:transmembrane transporter activity |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF00873; ACR_tran; 1; |
PRINTS | PR00702; ACRIFLAVINRP; 1; |
General | Transmembrane; -; 11-12; |
Features
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Additional information
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Size range | 1039-1056 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct. |