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Annotation rule MF_01433
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General rule information [?]

Accession MF_01433
Dates 20-DEC-2005 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Pyrim_hydro_RihB
Scope
Bacteria; Enterobacteriaceae
Template P33022 (RIHB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RIHB
Protein name
RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihB;
EC 3.2.2.8;
AltName: Full=Cytidine/uridine-specific hydrolase;
Gene name
rihB

Comments [?]

Function Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides.
Catalytic activity RHEA:56816: a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose
EC 3.2.2.8
case <FTGroup:1>
Cofactor Ca(2+)
Note: Binds 1 Ca(2+) ion per monomer.
end case
Subunit Homotetramer.
Similarity Belongs to the IUNH family. RihB subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005509; Molecular function: calcium ion binding.
end case
GO:0050263; Molecular function: ribosylpyrimidine nucleosidase activity.
GO:0006206; Biological process: pyrimidine nucleobase metabolic process.

Cross-references [?]

PROSITE PS01247; IUNH; 1;
Pfam PF01156; IU_nuc_hydro; 1;

Features [?]

From: RIHB_ECOLI (P33022)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     11     11       Proton acceptor     [DE]  
METAL     11     11       Calcium     [DE]   1
METAL     16     16       Calcium     D   1
METAL     124     124       Calcium; via carbonyl oxygen     V   1
METAL     240     240       Calcium     D   1
BINDING     227     227       Substrate     Q  
BINDING     239     239       Substrate     H  

Additional information [?]

Size range 313-313 amino acids
Related rules None
Fusion None