HAMAP logo

HAMAP rule MF_01433

Send feedback

General rule information [?]

Accession MF_01433
Dates 20-DEC-2005 (Created)
19-NOV-2022 (Last updated, Version 19)
Name Pyrim_hydro_RihB
Scope(s) Bacteria
Template(s) P33022 (RIHB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01433 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RIHB
Protein name RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihB;
AltName: Full=Cytidine/uridine-specific hydrolase;
Gene name Name=rihB;

Comments [?]

FUNCTIONHydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides.
CATALYTIC ACTIVITY Reaction=a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose; Xref=Rhea:RHEA:56816, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432, ChEBI:CHEBI:47013, ChEBI:CHEBI:141014; EC=;
case <FTGroup:1>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per monomer.;
end case
SIMILARITYBelongs to the IUNH family. RihB subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005509; Molecular function:calcium ion binding
end case
GO:0050263; Molecular function:ribosylpyrimidine nucleosidase activity
GO:0006206; Biological process:pyrimidine nucleobase metabolic process

Cross-references [?]

Pfam PF01156; IU_nuc_hydro; 1;

Features [?]

From: RIHB_ECOLI (P33022)
Key From To Description Tag Condition FTGroup
ACT_SITE 11 11 /note="Proton acceptor" [DE]
BINDING 11 11 /ligand="Ca(2+)"
[DE] 1
BINDING 16 16 /ligand="Ca(2+)"
D 1
BINDING 124 124 /ligand="Ca(2+)"
V 1
BINDING 240 240 /ligand="Ca(2+)"
D 1
BINDING 227 227 /ligand="substrate" Q
BINDING 239 239 /ligand="substrate" H

Additional information [?]

Size range 313-313 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)