HAMAP rule MF_01433
General rule information
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| Accession | MF_01433 |
| Dates | 20-DEC-2005 (Created)
19-NOV-2022 (Last updated, Version 19) |
| Name | Pyrim_hydro_RihB |
| Scope(s) |
Bacteria Enterobacteriaceae |
| Template(s) | P33022 (RIHB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01433 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RIHB |
| Protein name | RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihB; EC=3.2.2.8; AltName: Full=Cytidine/uridine-specific hydrolase; |
| Gene name | Name=rihB; |
Comments
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| FUNCTION | Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. |
| CATALYTIC ACTIVITY | Reaction=a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose; Xref=Rhea:RHEA:56816, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432, ChEBI:CHEBI:47013, ChEBI:CHEBI:141014; EC=3.2.2.8; |
| case <FTGroup:1> | |
| COFACTOR | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per monomer.; |
| end case | |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the IUNH family. RihB subfamily. |
Keywords
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| Glycosidase | |
| Hydrolase | |
| case <FTGroup:1> | |
| Calcium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0005509; Molecular function:calcium ion binding | |
| end case | |
| GO:0050263; Molecular function:ribosylpyrimidine nucleosidase activity | |
| GO:0006206; Biological process:pyrimidine nucleobase metabolic process | |
Cross-references
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Features
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| From: RIHB_ECOLI (P33022) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 11 | 11 | /note="Proton acceptor" | [DE] | ||||||||
| BINDING | 11 | 11 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
[DE] | 1 | |||||||
| BINDING | 16 | 16 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
D | 1 | |||||||
| BINDING | 124 | 124 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
V | 1 | |||||||
| BINDING | 240 | 240 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
D | 1 | |||||||
| BINDING | 227 | 227 | /ligand="substrate" | Q | ||||||||
| BINDING | 239 | 239 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 313-313 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |