HAMAP rule MF_01434
General rule information
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| Accession | MF_01434 |
| Dates | 15-DEC-2005 (Created)
11-NOV-2020 (Last updated, Version 20) |
| Name | MGT |
| Scope(s) |
Bacteria Staphylococcus |
| Template(s) | Q93Q23 (MGT_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_01434 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MGT |
| Protein name | RecName: Full=Monofunctional glycosyltransferase; Short=MGT; EC=2.4.1.129; AltName: Full=Peptidoglycan TGase; |
| Gene name | Name=mgt; |
Comments
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| FUNCTION | Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate. |
| CATALYTIC ACTIVITY | Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
| SIMILARITY | Belongs to the glycosyltransferase 51 family. |
Keywords
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| Cell membrane |
| Cell shape |
| Cell wall biogenesis/degradation |
| Glycosyltransferase |
| Membrane |
| Peptidoglycan synthesis |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF00912; Transgly; 1; |
| General | Transmembrane; -; 1; |
Features
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Additional information
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| Size range | 265-280 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |