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HAMAP rule MF_01443

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General rule information [?]

Accession MF_01443
Dates 12-JUL-2007 (Created)
15-FEB-2022 (Last updated, Version 13)
Name PrpE
Scope(s) Bacteria
Template(s) O31614 (PRPE_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01443 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRPE
Protein name RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical];
AltName: Full=Ap4A hydrolase;
AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase;
                 Short=Diadenosine tetraphosphatase;
Gene name Name=prpE;

Comments [?]

FUNCTIONAsymmetrically hydrolyzes Ap4p to yield AMP and ATP.
CATALYTIC ACTIVITY Reaction=H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+); Xref=Rhea:RHEA:22484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57553, ChEBI:CHEBI:58115; EC=;
COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
SIMILARITYBelongs to the PrpE family.

Keywords [?]

Gene Ontology [?]

GO:0004081; Molecular function:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0016151; Molecular function:nickel cation binding

Cross-references [?]

Pfam PF00149; Metallophos; 1;

Features [?]

Additional information [?]

Size range 244-250 amino acids
Related rules None
Fusion Nter: None Cter: None

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