HAMAP rule MF_01443

General rule information [?]

Accession	MF_01443
Dates	12-JUL-2007 (Created) 15-FEB-2022 (Last updated, Version 13)
Name	PrpE
Scope(s)	Bacteria Bacillaceae
Template(s)	O31614 (PRPE_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_01443 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PRPE
Protein name	RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical]; EC=3.6.1.17; AltName: Full=Ap4A hydrolase; AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Short=Diadenosine tetraphosphatase;
Gene name	Name=prpE;

Comments [?]

FUNCTION	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.
CATALYTIC ACTIVITY	Reaction=H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+); Xref=Rhea:RHEA:22484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57553, ChEBI:CHEBI:58115; EC=3.6.1.17;
COFACTOR	Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
SIMILARITY	Belongs to the PrpE family.

Keywords [?]

Gene Ontology [?]

GO:0004081; Molecular function:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity

GO:0016151; Molecular function:nickel cation binding

Cross-references [?]

Pfam	PF00149; Metallophos; 1;
PRINTS	PR00114; STPHPHTASE; 1;

Features [?]

Additional information [?]