HAMAP rule MF_01443
General rule information
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Accession | MF_01443 |
Dates | 12-JUL-2007 (Created)
15-FEB-2022 (Last updated, Version 13) |
Name | PrpE |
Scope(s) |
Bacteria Bacillaceae |
Template(s) | O31614 (PRPE_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01443 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PRPE |
Protein name | RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical]; EC=3.6.1.17; AltName: Full=Ap4A hydrolase; AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Short=Diadenosine tetraphosphatase; |
Gene name | Name=prpE; |
Comments
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FUNCTION | Asymmetrically hydrolyzes Ap4p to yield AMP and ATP. |
CATALYTIC ACTIVITY | Reaction=H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+); Xref=Rhea:RHEA:22484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57553, ChEBI:CHEBI:58115; EC=3.6.1.17; |
COFACTOR | Name=Ni(2+); Xref=ChEBI:CHEBI:49786; |
SIMILARITY | Belongs to the PrpE family. |
Keywords
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Gene Ontology
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GO:0004081; Molecular function:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
GO:0016151; Molecular function:nickel cation binding |
Cross-references
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Features
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Additional information
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Size range | 244-250 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |