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Annotation rule MF_01453 |
General rule information
[?]
Accession |
MF_01453 |
Dates |
4-JUN-2009 (Created) 19-NOV-2019 (Last updated, Version 15) |
Scope |
Bacteria; Firmicutes |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=ATP-dependent helicase/deoxyribonuclease subunit B;
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EC 3.1.-.-;
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EC 3.6.4.12;
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AltName:
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Full=ATP-dependent helicase/nuclease RexB;
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Function |
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. |
Catalytic activity |
RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12
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case <FTGroup:1>
end case
Cofactor |
Mg(2+) |
Subunit |
Heterodimer of AddA and RexB. |
Similarity |
Belongs to the helicase family. AddB/RexB type 2 subfamily. |
case <FTGroup:1>
end case
GO:0005524; Molecular function: ATP binding.
GO:0008409; Molecular function: 5'-3' exonuclease activity.
GO:0003690; Molecular function: double-stranded DNA binding.
case <FTGroup:1>
GO:0051536; Molecular function: iron-sulfur cluster binding.
end case
GO:0000724; Biological process: double-strand break repair via homologous recombination.
From: ADDB_LACLM (A2RH76) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL (Optional)
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766
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766
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL (Optional)
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1056
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1056
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL (Optional)
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1059
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1059
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL (Optional)
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1065
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1065
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Iron-sulfur (4Fe-4S)
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C
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1
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Additional information
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Size range |
1071-1260 amino acids |
Related rules |
MF_01452 (ADDB) |
Fusion |
None |
Comments |
The iron-sulfur center has been shown to exist in the related AddB protein from B.subtilis; its suggested presence in a few members of this family is based solely on sequence conservation. Two related subfamiles of this protein exist; addB in Bacillus and Staphylococcus (MF_01452), and rexB in Lactobacillus and Streptococcus (this family). In most Lactobacillales there is no 4Fe-4S center; this has been suggested (PubMed:19129187) to occur in organisms which inhabit a low- iron environment. |