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HAMAP rule MF_01454

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General rule information [?]

Accession MF_01454
Dates 3-SEP-2009 (Created)
1-JUN-2023 (Last updated, Version 17)
Name GTPase_Obg
Templates P42641 (OBG_ECOLI); P20964 (OBG_BACSU); B8GYI7 (OBG_CAUVN); Q6E0U3 (OBG_VIBHA); P95722 (OBG_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GTPase Obg;
EC 3.6.5.-;
AltName: Full=GTP-binding protein Obg;
Gene name

Comments [?]

Function An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Cofactor Mg(2+)
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

Keywords [?]

case <FT:6> or <FT:7>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0042254; Biological process: ribosome biogenesis.

Cross-references [?]

PROSITE PS51710; G_OBG; 1; trigger=PRU01047;
PS00905; GTP1_OBG; 1;
PS51881; OCT; 0-1; trigger=PRU01229;
PS51883; OBG; 1; trigger=PRU01231;
Pfam PF01018; GTP1_OBG; 1;
PF01926; MMR_HSR1; 1; trigger=Yes;
NCBIfam TIGR02729; Obg_CgtA; 1;
TIGR00231; Small_GTP; 1;
TIGR03595; Obg_CgtA_exten; 1;
PIRSF PIRSF002401; GTP_bd_Obg/CgtA; 1;

Features [?]

From: OBG_ECOLI (P42641)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     166     173       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-[FIKLMPRVY]-[PS]-[NS]-[ACSTV]-G-[KR]-S  
BINDING     191     195       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     F-[TS]-T-[LIKMR]-[VTHIESNYKAQFDR]  
BINDING     213     216       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [DE]-[ILMV]-P-[GS]  
BINDING     283     286       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [NST]-[KQR]-x-[DE]  
BINDING     314     316       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565        
BINDING     173     173       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]  
BINDING     193     193       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]  

Additional information [?]

Size range 326-534 amino acids
Related rules None
Fusion Nter: None; Cter: <Radical SAM domain>
Comments BRAHW is C-terminally fused to a radical SAM-type domain. It has been noted that "The C-terminal domains of these proteins, however, can vary in both length and sequence, which may result in functional differences between distantly related bacteria." PubMed:15554976