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Annotation rule MF_01454 |
Accession | MF_01454 |
Dates | 3-SEP-2009 (Created) 4-JUN-2021 (Last updated, Version 14) |
Name | GTPase_Obg |
Scope | Bacteria |
Templates | P42641 (OBG_ECOLI); P20964 (OBG_BACSU); B8GYI7 (OBG_CAUVN); Q6E0U3 (OBG_VIBHA); P95722 (OBG_STRCO): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. |
Cofactor | Mg(2+) |
Subunit | Monomer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. |
PROSITE | PS51710; G_OBG; 1; trigger=PRU01047; |
PS00905; GTP1_OBG; 1; | |
PS51881; OCT; 0-1; trigger=PRU01229; | |
PS51883; OBG; 1; trigger=PRU01231; | |
Pfam | PF01018; GTP1_OBG; 1; |
PF01926; MMR_HSR1; 1; trigger=Yes; | |
PRINTS | PR00326; GTP1OBG; 4; |
TIGRFAMs | TIGR02729; Obg_CgtA; 1; |
TIGR00231; Small_GTP; 1; | |
TIGR03595; Obg_CgtA_exten; 1; | |
PIRSF | PIRSF002401; GTP_bd_Obg/CgtA; 1; |
From: OBG_ECOLI (P42641) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 166 | 173 | GTP | G-[FIKLMPRVY]-[PS]-[NS]-[ACSTV]-G-[KR]-S | ||||||||
NP_BIND | 191 | 195 | GTP | F-[TS]-T-[LIKMR]-[VTHIESNYKAQFDR] | ||||||||
NP_BIND | 213 | 216 | GTP | [DE]-[ILMV]-P-[GS] | ||||||||
NP_BIND | 283 | 286 | GTP | [NST]-[KQR]-x-[DE] | ||||||||
NP_BIND | 314 | 316 | GTP | |||||||||
METAL | 173 | 173 | Magnesium | [ST] | ||||||||
METAL | 193 | 193 | Magnesium | [ST] |
Size range | 326-534 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: <Radical SAM domain> |
Comments | BRAHW is C-terminally fused to a radical SAM-type domain. It has been noted that "The C-terminal domains of these proteins, however, can vary in both length and sequence, which may result in functional differences between distantly related bacteria." PubMed:15554976 |