HAMAP rule MF_01454

General rule information [?]

Accession	MF_01454
Dates	3-SEP-2009 (Created) 1-JUN-2023 (Last updated, Version 17)

Name	GTPase_Obg

Scope

Bacteria

Templates

P42641 (OBG_ECOLI); P20964 (OBG_BACSU); B8GYI7 (OBG_CAUVN); Q6E0U3 (OBG_VIBHA); P95722 (OBG_STRCO): [Recover all]

Triggered by

HAMAP; MF_01454 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

OBG

Protein name

RecName:		Full=GTPase Obg;
		EC 3.6.5.-;
AltName:		Full=GTP-binding protein Obg;

Gene name

obg

Comments [?]

Function	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Cofactor	Mg(2+)
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

Keywords [?]

Cytoplasm
GTP-binding
Hydrolase

case <FT:6> or <FT:7>

Magnesium
Metal-binding

end case

Nucleotide-binding

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0042254; Biological process: ribosome biogenesis.

Cross-references [?]

PROSITE	PS51710; G_OBG; 1; trigger=PRU01047;
	PS00905; GTP1_OBG; 1;
	PS51881; OCT; 0-1; trigger=PRU01229;
	PS51883; OBG; 1; trigger=PRU01231;
Pfam	PF01018; GTP1_OBG; 1;
	PF01926; MMR_HSR1; 1; trigger=Yes;
PRINTS	PR00326; GTP1OBG; 4;
NCBIfam	TIGR02729; Obg_CgtA; 1;
	TIGR00231; Small_GTP; 1;
	TIGR03595; Obg_CgtA_exten; 1;
PIRSF	PIRSF002401; GTP_bd_Obg/CgtA; 1;

Features [?]

From: OBG_ECOLI (P42641)

Key From To Description Tag Condition FTGroup

BINDING 166 173 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 G-[FIKLMPRVY]-[PS]-[NS]-[ACSTV]-G-[KR]-S

BINDING 191 195 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 F-[TS]-T-[LIKMR]-[VTHIESNYKAQFDR]

BINDING 213 216 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 [DE]-[ILMV]-P-[GS]

BINDING 283 286 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 [NST]-[KQR]-x-[DE]

BINDING 314 316 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

BINDING 173 173 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [ST]

BINDING 193 193 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [ST]

Additional information [?]

Size range	326-534 amino acids
Related rules	None
Fusion	Nter: None; Cter: <Radical SAM domain>
Comments	BRAHW is C-terminally fused to a radical SAM-type domain. It has been noted that "The C-terminal domains of these proteins, however, can vary in both length and sequence, which may result in functional differences between distantly related bacteria." PubMed:15554976

View rule in raw text format (no links)