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HAMAP rule MF_01454

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General rule information [?]

Accession MF_01454
Dates 3-SEP-2009 (Created)
1-JUN-2023 (Last updated, Version 17)
Name GTPase_Obg
Scope(s) Bacteria
Template(s) P42641 (OBG_ECOLI); P20964 (OBG_BACSU); B8GYI7 (OBG_CAUVN); Q6E0U3 (OBG_VIBHA); P95722 (OBG_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01454 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier OBG
Protein name RecName: Full=GTPase Obg;
AltName: Full=GTP-binding protein Obg;
Gene name Name=obg;

Comments [?]

FUNCTIONAn essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
GO:0005737; Cellular component:cytoplasm
GO:0042254; Biological process:ribosome biogenesis

Cross-references [?]

PROSITE PS51710; G_OBG; 1;
PROSITE PS51881; OCT; 0-1;
PROSITE PS51883; OBG; 1;
Pfam PF01018; GTP1_OBG; 1;
Pfam PF01926; MMR_HSR1; 1;
NCBIfam TIGR02729; Obg_CgtA; 1;
NCBIfam TIGR00231; Small_GTP; 1;
NCBIfam TIGR03595; Obg_CgtA_exten; 1;
PIRSF PIRSF002401; GTP_bd_Obg/CgtA; 1;

Features [?]

From: OBG_ECOLI (P42641)
Key From To Description Tag Condition FTGroup
BINDING 166 173 /ligand="GTP"
BINDING 191 195 /ligand="GTP"
BINDING 213 216 /ligand="GTP"
BINDING 283 286 /ligand="GTP"
BINDING 314 316 /ligand="GTP"
BINDING 173 173 /ligand="Mg(2+)"
BINDING 193 193 /ligand="Mg(2+)"

Additional information [?]

Size range 326-534 amino acids
Related rules None
Fusion Nter: None Cter: <Radical SAM domain>
Comments BRAHW is C-terminally fused to a radical SAM-type domain. It has been noted that "The C-terminal domains of these proteins, however, can vary in both length and sequence, which may result in functional differences between distantly related bacteria." PubMed:15554976

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