HAMAP rule MF_01467
General rule information
[?]
Accession | MF_01467 |
Dates | 15-DEC-2011 (Created) 19-NOV-2019 (Last updated, Version 5) |
Name | Hypx_phosphoribosyltr |
Scope | Archaea; Euryarchaeota |
Template | O33174 (HPRT_METTM) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case not <OC:Halobacteria>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Halobacteria>
Identifier |
|
Protein name |
|
end case
Comments
[?]
case not <OC:Halobacteria>
Function | Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. |
Catalytic activity | RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
EC 2.4.2.8 |
RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine | |
Pathway | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
else case <OC:Halobacteria>
Function | May catalyze a purine salvage reaction, the substrate is unknown. |
end case
Similarity | Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. |
Keywords
[?]
case not <OC:Halobacteria>
end case
Gene Ontology
[?]
case not <OC:Halobacteria>
GO:0004422; Molecular function: hypoxanthine phosphoribosyltransferase activity.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
[?]
Additional information
[?]
Size range | 181-196 amino acids |
Related rules | None |
Fusion | None |
Comments | Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria. |