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| Annotation rule MF_01467 |
General rule information
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| Accession | MF_01467 |
| Dates | 15-DEC-2011 (Created) 19-NOV-2019 (Last updated, Version 5) |
| Name | Hypx_phosphoribosyltr |
| Scope | Archaea; Euryarchaeota |
| Template | O33174 (HPRT_METTM) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Halobacteria>
| Identifier |
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| Protein name |
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| Gene name |
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else case <OC:Halobacteria>
| Identifier |
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| Protein name |
|
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end case
Comments
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case not <OC:Halobacteria>
| Function | Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. |
| Catalytic activity | RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
EC 2.4.2.8 |
| RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine | |
| Pathway | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. |
| Subunit | Homodimer. |
| Subcellular location | Cytoplasm. |
else case <OC:Halobacteria>
| Function | May catalyze a purine salvage reaction, the substrate is unknown. |
end case
| Similarity | Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. |
Keywords
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case not <OC:Halobacteria>
end case
Gene Ontology
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case not <OC:Halobacteria>
GO:0004422; Molecular function: hypoxanthine phosphoribosyltransferase activity.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
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Additional information
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| Size range | 181-196 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria. |