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Annotation rule MF_01467 |
General rule information
[?]
Accession |
MF_01467 |
Dates |
15-DEC-2011 (Created) 19-NOV-2019 (Last updated, Version 5) |
Name |
Hypx_phosphoribosyltr |
Scope |
Archaea; Euryarchaeota |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case not <OC:Halobacteria>
Protein name |
RecName:
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Full=Hypoxanthine/guanine phosphoribosyltransferase;
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Short=HGPRTase;
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EC 2.4.2.8;
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else case <OC:Halobacteria>
end case
case not <OC:Halobacteria>
Function |
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. |
Catalytic activity |
RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
EC 2.4.2.8
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RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
|
Pathway |
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. |
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
else case <OC:Halobacteria>
Function |
May catalyze a purine salvage reaction, the substrate is unknown. |
end case
Similarity |
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. |
case not <OC:Halobacteria>
end case
case not <OC:Halobacteria>
GO:0004422; Molecular function: hypoxanthine phosphoribosyltransferase activity.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
end case
PROSITE |
PS00103; PUR_PYR_PR_TRANSFER; 1; |
Pfam |
PF00156; Pribosyltran; 1; |
Additional information
[?]
Size range |
181-196 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria. |