HAMAP rule MF_01467
General rule information
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| Accession | MF_01467 |
| Dates | 15-DEC-2011 (Created)
8-OCT-2024 (Last updated, Version 8) |
| Name | Hypx_phosphoribosyltr |
| Scope(s) |
Archaea Methanobacteriati |
| Template(s) | O33174 (HPRT_METTM); [ Recover all ] |
| Triggered by |
HAMAP; MF_01467 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case not <OC:Halobacteria> | |
| Identifier | HPRT |
| Protein name | RecName: Full=Hypoxanthine/guanine phosphoribosyltransferase; Short=HGPRTase; EC=2.4.2.8; |
| Gene name | Name=hpt; |
| else case <OC:Halobacteria> | |
| Identifier | HPRL |
| Protein name | RecName: Full=HGPRTase-like protein; EC=2.4.2.-; |
| end case | |
Comments
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| case not <OC:Halobacteria> | |
| FUNCTION | Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. |
| CATALYTIC ACTIVITY | Reaction=IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1- diphosphate; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8; |
| CATALYTIC ACTIVITY | Reaction=GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1- diphosphate; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58115; |
| PATHWAY | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| else case <OC:Halobacteria> | |
| FUNCTION | May catalyze a purine salvage reaction, the substrate is unknown. |
| end case | |
| SIMILARITY | Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. |
Keywords
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| case not <OC:Halobacteria> | |
| Cytoplasm | |
| Glycosyltransferase | |
| end case | |
| Purine salvage | |
| Transferase | |
Gene Ontology
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| case not <OCellular component:Halobacteria> | |
| GO:0004422; Molecular function:hypoxanthine phosphoribosyltransferase activity | |
| GO:0032264; Biological process:IMP salvage | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 181-196 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria. |