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HAMAP rule MF_01467

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General rule information [?]

Accession MF_01467
Dates 15-DEC-2011 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Hypx_phosphoribosyltr
Scope(s) Archaea
Template(s) O33174 (HPRT_METTM); [ Recover all ]
Triggered by HAMAP; MF_01467 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Halobacteria>
Identifier HPRT
Protein name RecName: Full=Hypoxanthine/guanine phosphoribosyltransferase;
Gene name Name=hpt;
else case <OC:Halobacteria>
Identifier HPRL
Protein name RecName: Full=HGPRTase-like protein;
end case

Comments [?]

case not <OC:Halobacteria>
FUNCTIONCatalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
CATALYTIC ACTIVITY Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=;
CATALYTIC ACTIVITY Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58115;
PATHWAYPurine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
else case <OC:Halobacteria>
FUNCTIONMay catalyze a purine salvage reaction, the substrate is unknown.
end case
SIMILARITYBelongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.

Keywords [?]

case not <OC:Halobacteria>
end case
Purine salvage

Gene Ontology [?]

case not <OCellular component:Halobacteria>
GO:0004422; Molecular function:hypoxanthine phosphoribosyltransferase activity
GO:0043103; Biological process:hypoxanthine salvage
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF00156; Pribosyltran; 1;

Features [?]

Additional information [?]

Size range 181-196 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria.

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