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HAMAP rule MF_01467

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General rule information [?]

Accession MF_01467
Dates 15-DEC-2011 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Hypx_phosphoribosyltr
Scope
Archaea; Euryarchaeota
Template O33174 (HPRT_METTM)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case not <OC:Halobacteria>
Identifier
HPRT
Protein name
RecName: Full=Hypoxanthine/guanine phosphoribosyltransferase;
Short=HGPRTase;
EC 2.4.2.8;
Gene name
hpt
else case <OC:Halobacteria>
Identifier
HPRL
Protein name
RecName: Full=HGPRTase-like protein;
EC 2.4.2.-;
end case

Comments [?]

case not <OC:Halobacteria>
Function Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
Catalytic activity RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
EC 2.4.2.8
RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
Pathway Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
else case <OC:Halobacteria>
Function May catalyze a purine salvage reaction, the substrate is unknown.
end case
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.

Keywords [?]

case not <OC:Halobacteria>
Cytoplasm
Glycosyltransferase
end case
Purine salvage
Transferase

Gene Ontology [?]

case not <OC:Halobacteria>
GO:0004422; Molecular function: hypoxanthine phosphoribosyltransferase activity.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam PF00156; Pribosyltran; 1;

Additional information [?]

Size range 181-196 amino acids
Related rules None
Fusion None
Comments Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria.


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