HAMAP rule MF_01470

General rule information [?]

Accession	MF_01470
Dates	26-MAR-2012 (Created) 1-JUN-2023 (Last updated, Version 29)

Name

Cas1

Scope

Bacteria

Archaea

Templates

Q02ML7 (CAS1_PSEAB); Q46896 (CAS1_ECOLI): [Recover all]

Triggered by

HAMAP; MF_01470 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CAS1

Protein name

RecName:		Full=CRISPR-associated endonuclease Cas1;
		EC 3.1.-.-;

Gene name

cas1

Comments [?]

Function	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Cofactor	Mg(2+) Mn(2+)
Subunit	Homodimer, forms a heterotetramer with a Cas2 homodimer.
Similarity	Belongs to the CRISPR-associated endonuclease Cas1 family.

Keywords [?]

Antiviral defense
DNA-binding
Endonuclease
Hydrolase
Magnesium
Manganese
Metal-binding
Nuclease

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
GO:0046872; Molecular function: metal ion binding.
GO:0051607; Biological process: defense response to virus.
GO:0043571; Biological process: maintenance of CRISPR repeat elements.

Cross-references [?]

Pfam	PF01867; Cas_Cas1; 1;
NCBIfam	TIGR00287; Cas1; 1;

Features [?]

From: CAS1_PSEAB (Q02ML7)

Key From To Description Tag Condition FTGroup

BINDING 190 190 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 E

BINDING 254 254 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 H

BINDING 268 268 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 [DE]

Additional information [?]

Size range	250-437 amino acids
Related rules	None
Fusion	Nter: <Cas4>, <Reverse transcriptase>; Cter: None
Comments	Frequently duplicated, there are many subfamiles, this one however is the master family. Sometimes found fused after Cas4 or a reverse transcriptase domain. One of the METRM (Q2FPW6) is missing residues predicted to be involved in metal-binding and is atypical.

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