HAMAP rule MF_01477
General rule information
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| Accession | MF_01477 |
| Dates | 16-AUG-2012 (Created) 1-JUN-2023 (Last updated, Version 8) |
| Name | Iojap_RsfS |
| Scope | Bacteria |
| Templates | P0AAT6 (IOJAP_ECOLI); Q96EH3 (MASU1_HUMAN); Q41822 (IOJAP_MAIZE): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. |
| Subunit | Interacts with ribosomal protein uL14 (rplN). |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the Iojap/RsfS family. |
Keywords
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Gene Ontology
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GO:0042256; Biological process: cytosolic ribosome assembly.
GO:0090071; Biological process: negative regulation of ribosome biogenesis.
GO:0017148; Biological process: negative regulation of translation.
GO:0005737; Cellular component: cytoplasm.
GO:0090071; Biological process: negative regulation of ribosome biogenesis.
GO:0017148; Biological process: negative regulation of translation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Additional information
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| Size range | 102-234 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Eukaryotic orthologs act in mitochondria and plastids. In human mitochondria they prevent association of the ribosomal subunits and affect translation in an uncharacterized fashion in maize plastids. |