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Annotation rule MF_01492
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General rule information [?]

Accession MF_01492
Dates 9-MAY-2014 (Created)
19-NOV-2019 (Last updated, Version 7)
Name RNase_J_arch
Scope
Archaea
Template Q9V076 (RNJ_PYRAB)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RNJ
Protein name
RecName: Full=Ribonuclease J;
Short=RNase J;
EC 3.1.-.-;
Gene name
rnj

Comments [?]

Function An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
Subunit Homodimer.
case <FTGroup:1> or <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

Gene Ontology [?]

GO:0004534; Molecular function: 5'-3' exoribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS01292; UPF0036; 1;
Pfam PF00753; Lactamase_B; 1;
PF07521; RMMBL; 1;
TIGRFAMs TIGR00649; MG423; 1;

Features [?]

From: RNJ_PYRAB (Q9V076)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     84     84       Zinc 1; catalytic     H   1
METAL     86     86       Zinc 1; catalytic     H   1
METAL (Optional)     88     88       Zinc 2; catalytic     D   2
METAL (Optional)     89     89       Zinc 2; catalytic     H   2
METAL     155     155       Zinc 1; catalytic     H   1
METAL     177     177       Zinc 1; catalytic     [DE]   1
METAL (Optional)     177     177       Zinc 2; catalytic     [DE]   2
METAL (Optional)     410     410       Zinc 2; catalytic     H   2
REGION     384     388       Substrate binding     H-[VTA]-S-[GS]-H  

Additional information [?]

Size range 399-475 amino acids
Related rules MF_01491 (RNJ)
Fusion None
Comments Duplicated in a few Archaea. A closely-related protein exists in bacteria, which is about 100 residues longer at the C-terminus and has exo- and endoribonuclease activity.