HAMAP rule MF_01492
General rule information
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Accession | MF_01492 |
Dates | 9-MAY-2014 (Created) 1-JUN-2023 (Last updated, Version 12) |
Name | RNase_J_arch |
Scope | Archaea |
Template | Q9V076 (RNJ_PYRAB) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation. |
Subunit | Homodimer. |
case <FTGroup:1> or <FTGroup:2>
Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. |
Keywords
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case <FTGroup:1> or <FTGroup:2>
end case
Gene Ontology
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GO:0004534; Molecular function: 5'-3' RNA exonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0006401; Biological process: RNA catabolic process.
case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS01292; UPF0036; 1; |
Pfam | PF00753; Lactamase_B; 1; |
PF07521; RMMBL; 1; | |
NCBIfam | TIGR00649; MG423; 1; |
Features
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From: RNJ_PYRAB (Q9V076) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 84 | 84 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 86 | 86 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING (Optional) | 88 | 88 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | D | 2 | |||||||
BINDING (Optional) | 89 | 89 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | H | 2 | |||||||
BINDING | 155 | 155 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 177 | 177 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | [DE] | 1 | |||||||
BINDING (Optional) | 177 | 177 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | [DE] | 2 | |||||||
BINDING (Optional) | 410 | 410 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | H | 2 | |||||||
BINDING | 384 | 388 | /ligand="substrate | H-[VTA]-S-[GS]-H |
Additional information
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Size range | 399-475 amino acids |
Related rules | MF_01491 (RNJ) |
Fusion | None |
Comments | Duplicated in a few Archaea. A closely-related protein exists in bacteria, which is about 100 residues longer at the C-terminus and has exo- and endoribonuclease activity. |