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HAMAP rule MF_01501

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General rule information [?]

Accession MF_01501
Dates 4-DEC-2003 (Created)
1-JUN-2023 (Last updated, Version 18)
Name MtrH
Scope(s) Archaea
Template(s) P80187 (MTRH_METTM); [ Recover all ]
Triggered by HAMAP; MF_01501 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTRH
Protein name RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H;
Gene name Name=mtrH;

Comments [?]

FUNCTIONPart of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
CATALYTIC ACTIVITY Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101, ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286, ChEBI:CHEBI:58319; EC=;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case
SUBUNITThe complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
SIMILARITYBelongs to the MtrH family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case
One-carbon metabolism

Gene Ontology [?]

GO:0030269; Molecular function:tetrahydromethanopterin S-methyltransferase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process:methanogenesis
end case

Cross-references [?]

Pfam PF02007; MtrH; 1;
NCBIfam TIGR01114; MtrH; 1;

Features [?]

Additional information [?]

Size range 310-322 amino acids
Related rules None
Fusion Nter: None Cter: None

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