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Annotation rule MF_01501
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General rule information [?]

Accession MF_01501
Dates 4-DEC-2003 (Created)
19-NOV-2019 (Last updated, Version 17)
Name MtrH
Template P80187 (MTRH_METTM)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H;
Gene name

Comments [?]

Function Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
Catalytic activity RHEA:53492: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case
Subunit The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
Similarity Belongs to the MtrH family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case

Gene Ontology [?]

GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case

Cross-references [?]

Pfam PF02007; MtrH; 1;
TIGRFAMs TIGR01114; MtrH; 1;

Additional information [?]

Size range 310-322 amino acids
Related rules None
Fusion None