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HAMAP rule MF_01510

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General rule information [?]

Accession MF_01510
Dates 11-FEB-2004 (Created)
1-JUN-2023 (Last updated, Version 24)
Name GMP_synthase_A
Scope(s) Archaea
Template(s) P04079 (GUAA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01510 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GUAAA
Protein name RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit A;
AltName: Full=Glutamine amidotransferase;
Gene name Name=guaAA;

Comments [?]

FUNCTIONCatalyzes the synthesis of GMP from XMP.
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=;
PATHWAYPurine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
SUBUNITHeterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

Keywords [?]

Gene Ontology [?]

GO:0003922; Molecular function:GMP synthase (glutamine-hydrolyzing) activity
GO:0006177; Biological process:GMP biosynthetic process

Cross-references [?]

Pfam PF00117; GATase; 1;
NCBIfam TIGR00888; GuaA_Nterm; 1;

Features [?]

From: GUAAA_METJA (Q58970)
Key From To Description Tag Condition FTGroup
ACT_SITE 76 76 /note="Nucleophile" C
ACT_SITE 163 163 H
ACT_SITE 165 165 E

Additional information [?]

Size range 181-202 amino acids
Related rules MF_00344
Fusion Nter: None Cter: None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain

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