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Annotation rule MF_01511
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General rule information [?]

Accession MF_01511
Dates 17-FEB-2004 (Created)
19-NOV-2019 (Last updated, Version 15)
Name GMP_reduct_type2
Scope
Bacteria; Firmicutes
Bacteria; Betaproteobacteria
Bacteria; Campylobacterales
Template O05269 (GUAC_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAC
Protein name
RecName: Full=GMP reductase;
EC 1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
Gene name
guaC

Comments [?]

Function Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
Similarity Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Keywords [?]

Oxidoreductase
NADP

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

Pfam PF00478; IMPDH; 1;
TIGRFAMs TIGR01306; GMP_reduct_2; 1;
PROSITE PS00487; IMP_DH_GMP_RED; 1;

Features [?]

From: GUAC_BACSU (O05269)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     204     227       NADP        
ACT_SITE     175     175       Thioimidate intermediate     C  

Additional information [?]

Size range 316-330 amino acids
Related rules None
Fusion None


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