HAMAP rule MF_01511
General rule information
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Accession | MF_01511 |
Dates | 17-FEB-2004 (Created) 1-JUN-2023 (Last updated, Version 19) |
Name | GMP_reduct_type2 |
Scope | Bacteria; Bacillota
Bacteria; Betaproteobacteria
Bacteria; Campylobacterales |
Template | O05269 (GUAC_BACSU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
Catalytic activity | RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7 |
Similarity | Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
GO:0006163; Biological process: purine nucleotide metabolic process.
Cross-references
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Features
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From: GUAC_BACSU (O05269) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 204 | 227 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
ACT_SITE | 175 | 175 | Thioimidate intermediate | C |
Additional information
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Size range | 316-330 amino acids |
Related rules | None |
Fusion | None |