HAMAP rule MF_01511
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01511 |
| Accession | MF_01511 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 18) |
| Name | GMP_reduct_type2 |
| Scope(s) |
Bacteria Bacillota Betaproteobacteria Campylobacterales |
| Template(s) | O05269; [ Recover all ] |
| Triggered by |
HAMAP; MF_01511 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GUAC |
| Protein name | RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase; |
| Gene name | Name=guaC; |
Comments
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| FUNCTION | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
| CATALYTIC ACTIVITY | Reaction=IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+); Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; |
| SIMILARITY | Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0003920; Molecular function:GMP reductase activity |
| GO:0006163; Biological process:purine nucleotide metabolic process |
Cross-references
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Features
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| From: GUAC_BACSU (O05269) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 204 | 227 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
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| ACT_SITE | 175 | 175 | /note="Thioimidate intermediate" | C | ||||||||
Additional information
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| Size range | 316-330 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |