HAMAP rule MF_01521

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01521
Accession	MF_01521
Dates	28-FEB-2005 (Created) 24-JUN-2025 (Last updated, Version 39)
Name	MntP_exporter
Scope(s)	Bacteria Archaea
Template(s)	P76264; [ Recover all ]
Triggered by	HAMAP; MF_01521 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MNTP
Protein name	RecName: Full=Manganese exporter MntP;
Gene name	Name=mntP;

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FUNCTION	Functions as a manganese exporter. Involved in manganese homeostasis. Important for reducing the concentration of manganese in the cell when manganese levels are high, thus reducing its toxicity.
else
FUNCTION	Functions as a manganese exporter.
end case
CATALYTIC ACTIVITY	Reaction=Mn(2+)(in) = Mn(2+)(out); Xref=Rhea:RHEA:28699, ChEBI:CHEBI:29035; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28700;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the MntP (TC 9.B.29) family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Ion transport
Manganese
Membrane
Transmembrane
Transmembrane helix
Transport

Gene Ontology [?]

GO:0071421; Biological process:manganese ion transmembrane transport

GO:0005384; Molecular function:manganese ion transmembrane transporter activity

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF02659; DUF204; 1;
General	Transmembrane; -; 5-7;

Features [?]

Additional information [?]