HAMAP rule MF_01527
General rule information
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| Accession | MF_01527 |
| Dates | 17-JAN-2005 (Created)
3-SEP-2024 (Last updated, Version 41) |
| Name | GTP_cyclohydrol |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q58185 (MPTA_METJA); P94398 (GCH4_BACSU); Q5F9K6 (GCH4_NEIG1); Q9WXP6 (GCH4_THEMA); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01527_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_01527_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacteria> | |
| Identifier | GCH4 |
| Protein name | RecName: Full=GTP cyclohydrolase FolE2; EC=3.5.4.16; |
| Gene name | Name=folE2; |
| end case | |
| case <OC:Archaea> | |
| Identifier | MPTA |
| Protein name | RecName: Full=GTP cyclohydrolase MptA; EC=3.5.4.39; AltName: Full=GTP cyclohydrolase IV; |
| Gene name | Name=mptA; |
| end case | |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Converts GTP to 7,8-dihydroneopterin triphosphate. |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16; |
| PATHWAY | Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. |
| end case | |
| case <OC:Archaea> | |
| FUNCTION | Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate + H(+); Xref=Rhea:RHEA:25860, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58854; EC=3.5.4.39; |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.; |
| PATHWAY | Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the GTP cyclohydrolase IV family. |
Keywords
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| Hydrolase | |
| case <OC:Archaea> | |
| Iron | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <OCellular component:Bacteria> | |
| GO:0003934; Molecular function:GTP cyclohydrolase I activity | |
| GO:0046654; Biological process:tetrahydrofolate biosynthetic process | |
| end case | |
| case <OCellular component:Archaea> | |
| GO:0044682; Molecular function:GTP cyclohydrolase IV activity | |
| GO:0005506; Molecular function:iron ion binding | |
| GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: GCH4_BACSU (P94398) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| SITE | 183 | 183 | /note="May be catalytically important" | C | ||||||||
| end case | ||||||||||||
| From: MPTA_METJA (Q58185) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| SITE | 160 | 160 | /note="May be catalytically important" | C | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 251-367 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The bacterial GTP cyclohydrolases of this family share the same function as the GTP cyclohydrolases of the MF_00223 family (GTP cyclohydrolases 1), without having any sequence homology. They are orthologs to the archaeal GTP cyclohydrolases (mptA), which have a new catalytic activity that is different from that of the bacterial cyclohydrolases. |