HAMAP rule MF_01535
General rule information
[?]
| Accession | MF_01535 |
| Dates | 29-MAR-2005 (Created)
1-JUN-2023 (Last updated, Version 25) |
| Name | Rhamnulokinase |
| Scope(s) |
Bacteria |
| Template(s) | P32171 (RHAB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01535 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | RHAB |
| Protein name | RecName: Full=Rhamnulokinase; Short=RhaB; EC=2.7.1.5; AltName: Full=Rhamnulose kinase; AltName: Full=L-rhamnulose 1-kinase; AltName: Full=ATP:L-rhamnulose phosphotransferase; |
| Gene name | Name=rhaB; |
Comments
[?]
| FUNCTION | Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. |
| CATALYTIC ACTIVITY | Reaction=ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate; Xref=Rhea:RHEA:20117, ChEBI:CHEBI:15378, ChEBI:CHEBI:17897, ChEBI:CHEBI:30616, ChEBI:CHEBI:58313, ChEBI:CHEBI:456216; EC=2.7.1.5; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 2/3. |
| case <OC:Escherichia> | |
| SUBUNIT | Monomer. |
| end case | |
| SIMILARITY | Belongs to the rhamnulokinase family. |
Keywords
[?]
| ATP-binding | |
| Kinase | |
| Magnesium | |
| Nucleotide-binding | |
| Rhamnose metabolism | |
| Transferase | |
| case <FT:9> or <FT:10> or <FT:11> | |
| Disulfide bond | |
| end case | |
Gene Ontology
[?]
| GO:0008993; Molecular function:rhamnulokinase activity |
| GO:0019299; Biological process:rhamnose metabolic process |
Cross-references
[?]
Features
[?]
| From: RHAB_ECOLI (P32171) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 13 | 17 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
A-[ST]-x(2)-R | ||||||||
| BINDING | 236 | 238 | /ligand="substrate" | H-D-T | ||||||||
| ACT_SITE | 237 | 237 | /note="Proton acceptor" | D | ||||||||
| BINDING | 83 | 83 | /ligand="substrate" | [GA] | ||||||||
| BINDING | 259 | 259 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
| BINDING | 296 | 296 | /ligand="substrate" | N | ||||||||
| BINDING | 304 | 304 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[QNE] | ||||||||
| BINDING | 402 | 402 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| DISULFID | 68 | 222 | C-x*-C | |||||||||
| DISULFID | 353 | 370 | C-x*-C | |||||||||
| DISULFID | 413 | 417 | C-x*-C | |||||||||
Additional information
[?]
| Size range | 467-496 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_00541 (rhaA) |