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HAMAP rule MF_01537

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General rule information [?]

Accession MF_01537
Dates 15-JUN-2005 (Created)
23-NOV-2021 (Last updated, Version 23)
Name Nucleos_phosphorylase_PpnP
Scope(s) Bacteria
Template(s) P0C037 (PPNP_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01537 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PPNP
Protein name RecName: Full=Pyrimidine/purine nucleoside phosphorylase;
AltName: Full=Adenosine phosphorylase;
AltName: Full=Cytidine phosphorylase;
AltName: Full=Guanosine phosphorylase;
AltName: Full=Inosine phosphorylase;
AltName: Full=Thymidine phosphorylase;
AltName: Full=Uridine phosphorylase;
AltName: Full=Xanthosine phosphorylase;
Gene name Name=ppnP;

Comments [?]

FUNCTIONCatalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
CATALYTIC ACTIVITY Reaction=a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:19805, ChEBI:CHEBI:26386, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720, ChEBI:CHEBI:142355; EC=;
CATALYTIC ACTIVITY Reaction=adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:27642, ChEBI:CHEBI:16335, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
CATALYTIC ACTIVITY Reaction=cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine; Xref=Rhea:RHEA:52540, ChEBI:CHEBI:16040, ChEBI:CHEBI:17562, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
CATALYTIC ACTIVITY Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
CATALYTIC ACTIVITY Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
CATALYTIC ACTIVITY Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=;
CATALYTIC ACTIVITY Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil; Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
CATALYTIC ACTIVITY Reaction=phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine; Xref=Rhea:RHEA:27638, ChEBI:CHEBI:17712, ChEBI:CHEBI:18107, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=;
SIMILARITYBelongs to the nucleoside phosphorylase PpnP family.

Keywords [?]

Gene Ontology [?]

GO:0004731; Molecular function:purine-nucleoside phosphorylase activity
GO:0016154; Molecular function:pyrimidine-nucleoside phosphorylase activity

Cross-references [?]

Pfam PF06865; DUF1255; 1;

Features [?]

Additional information [?]

Size range 92-111 amino acids
Related rules None
Fusion Nter: None Cter: None

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