HAMAP rule MF_01537
General rule information
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Accession | MF_01537 |
Dates | 15-JUN-2005 (Created)
23-NOV-2021 (Last updated, Version 23) |
Name | Nucleos_phosphorylase_PpnP |
Scope(s) |
Bacteria |
Template(s) | P0C037 (PPNP_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01537 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PPNP |
Protein name | RecName: Full=Pyrimidine/purine nucleoside phosphorylase; EC=2.4.2.1; EC=2.4.2.2; AltName: Full=Adenosine phosphorylase; AltName: Full=Cytidine phosphorylase; AltName: Full=Guanosine phosphorylase; AltName: Full=Inosine phosphorylase; AltName: Full=Thymidine phosphorylase; AltName: Full=Uridine phosphorylase; AltName: Full=Xanthosine phosphorylase; |
Gene name | Name=ppnP; |
Comments
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FUNCTION | Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. |
CATALYTIC ACTIVITY | Reaction=a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:19805, ChEBI:CHEBI:26386, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720, ChEBI:CHEBI:142355; EC=2.4.2.1; |
CATALYTIC ACTIVITY | Reaction=adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:27642, ChEBI:CHEBI:16335, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; |
CATALYTIC ACTIVITY | Reaction=cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine; Xref=Rhea:RHEA:52540, ChEBI:CHEBI:16040, ChEBI:CHEBI:17562, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.2; |
CATALYTIC ACTIVITY | Reaction=guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine; Xref=Rhea:RHEA:13233, ChEBI:CHEBI:16235, ChEBI:CHEBI:16750, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; |
CATALYTIC ACTIVITY | Reaction=inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine; Xref=Rhea:RHEA:27646, ChEBI:CHEBI:17368, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; |
CATALYTIC ACTIVITY | Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.2; |
CATALYTIC ACTIVITY | Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil; Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.2; |
CATALYTIC ACTIVITY | Reaction=phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine; Xref=Rhea:RHEA:27638, ChEBI:CHEBI:17712, ChEBI:CHEBI:18107, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.1; |
SIMILARITY | Belongs to the nucleoside phosphorylase PpnP family. |
Keywords
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Gene Ontology
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GO:0004731; Molecular function:purine-nucleoside phosphorylase activity |
GO:0016154; Molecular function:pyrimidine-nucleoside phosphorylase activity |
Cross-references
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Pfam | PF06865; DUF1255; 1; |
Features
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Additional information
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Size range | 92-111 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |