HAMAP rule MF_01559
General rule information
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| Accession | MF_01559 |
| Dates | 13-DEC-2005 (Created)
26-JAN-2023 (Last updated, Version 24) |
| Name | L_lact_dehydr |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P33232 (LLDD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01559 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LLDD |
| Protein name | RecName: Full=L-lactate dehydrogenase; EC=1.1.-.-; |
| Gene name | Name=lldD; |
Comments
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| FUNCTION | Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. |
| CATALYTIC ACTIVITY | Reaction=(S)-lactate + A = AH2 + pyruvate; Xref=Rhea:RHEA:45816, ChEBI:CHEBI:13193, ChEBI:CHEBI:15361, ChEBI:CHEBI:16651, ChEBI:CHEBI:17499; |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| case <OC:Pseudomonas> | |
| SUBUNIT | Homotetramer. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
| SIMILARITY | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Flavoprotein | |
| FMN | |
| Oxidoreductase | |
Gene Ontology
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| GO:0016614; Molecular function:oxidoreductase activity, acting on CH-OH group of donors |
| GO:0019516; Biological process:lactate oxidation |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS00557; FMN_HYDROXY_ACID_DH_1; 1; |
| PROSITE | PS51349; FMN_HYDROXY_ACID_DH_2; 1; |
| Pfam | PF01070; FMN_dh; 1; |
| PIRSF | PIRSF000138; Al-hdrx_acd_dh; 1; |
Features
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| From: LLDD_ECOLI (P33232) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 306 | 330 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
|||||||||
| ACT_SITE | 275 | 275 | /note="Proton acceptor" | H | ||||||||
| BINDING | 24 | 24 | /ligand="substrate" | Y | ||||||||
| BINDING | 106 | 106 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S | ||||||||
| BINDING | 127 | 127 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
Q | ||||||||
| BINDING | 129 | 129 | /ligand="substrate" | Y | ||||||||
| BINDING | 155 | 155 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
T | ||||||||
| BINDING | 164 | 164 | /ligand="substrate" | R | ||||||||
| BINDING | 251 | 251 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
K | ||||||||
| BINDING | 278 | 278 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 378-401 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |