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HAMAP rule MF_01559

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General rule information [?]

Accession MF_01559
Dates 13-DEC-2005 (Created)
26-JAN-2023 (Last updated, Version 24)
Name L_lact_dehydr
Bacteria; Pseudomonadota
Template P33232 (LLDD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=L-lactate dehydrogenase;
EC 1.1.-.-;
Gene name

Comments [?]

Function Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
Catalytic activity RHEA:45816: (S)-lactate + A = AH2 + pyruvate
Cofactor FMN
case <OC:Pseudomonas>
Subunit Homotetramer.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0016614; Molecular function: oxidoreductase activity, acting on CH-OH group of donors.
GO:0019516; Biological process: lactate oxidation.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PS51349; FMN_HYDROXY_ACID_DH_2; 1; trigger=PRU00683;
Pfam PF01070; FMN_dh; 1;
PIRSF PIRSF000138; Al-hdrx_acd_dh; 1;

Features [?]

From: LLDD_ECOLI (P33232)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     306     330       /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210        
ACT_SITE     275     275       Proton acceptor     H  
BINDING     24     24       /ligand="substrate     Y  
BINDING     106     106       /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210     S  
BINDING     127     127       /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210     Q  
BINDING     129     129       /ligand="substrate     Y  
BINDING     155     155       /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210     T  
BINDING     164     164       /ligand="substrate     R  
BINDING     251     251       /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210     K  
BINDING     278     278       /ligand="substrate     R  

Additional information [?]

Size range 378-401 amino acids
Related rules None
Fusion None