HAMAP rule MF_01559
General rule information
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| Accession | MF_01559 |
| Dates | 13-DEC-2005 (Created) 26-JAN-2023 (Last updated, Version 24) |
| Name | L_lact_dehydr |
| Scope | Bacteria; Pseudomonadota |
| Template | P33232 (LLDD_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. |
| Catalytic activity | RHEA:45816: (S)-lactate + A = AH2 + pyruvate |
| Cofactor | FMN |
case <OC:Pseudomonas>
| Subunit | Homotetramer. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Peripheral membrane protein. |
end case
| Similarity | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0016614; Molecular function: oxidoreductase activity, acting on CH-OH group of donors.
GO:0019516; Biological process: lactate oxidation.
GO:0005886; Cellular component: plasma membrane.
GO:0019516; Biological process: lactate oxidation.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS00557; FMN_HYDROXY_ACID_DH_1; 1; |
| PS51349; FMN_HYDROXY_ACID_DH_2; 1; trigger=PRU00683; | |
| Pfam | PF01070; FMN_dh; 1; |
| PIRSF | PIRSF000138; Al-hdrx_acd_dh; 1; |
Features
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| From: LLDD_ECOLI (P33232) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 306 | 330 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | |||||||||
| ACT_SITE | 275 | 275 | Proton acceptor | H | ||||||||
| BINDING | 24 | 24 | /ligand="substrate | Y | ||||||||
| BINDING | 106 | 106 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | S | ||||||||
| BINDING | 127 | 127 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | Q | ||||||||
| BINDING | 129 | 129 | /ligand="substrate | Y | ||||||||
| BINDING | 155 | 155 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | T | ||||||||
| BINDING | 164 | 164 | /ligand="substrate | R | ||||||||
| BINDING | 251 | 251 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | K | ||||||||
| BINDING | 278 | 278 | /ligand="substrate | R | ||||||||
Additional information
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| Size range | 378-401 amino acids |
| Related rules | None |
| Fusion | None |