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HAMAP rule MF_01589

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General rule information [?]

Accession MF_01589
Dates 29-NOV-2007 (Created)
1-JUN-2023 (Last updated, Version 20)
Name Cx_SAM_synthase
Scope(s) Bacteria
Template(s) P76290 (CMOA_ECOLI); Q7CQC4 (CMOA_SALTY); P43985 (CMOA_HAEIN); [ Recover all ]
Triggered by HAMAP; MF_01589 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CMOA
Protein name RecName: Full=Carboxy-S-adenosyl-L-methionine synthase;
                 Short=Cx-SAM synthase;
Gene name Name=cmoA;

Comments [?]

FUNCTIONCatalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
CATALYTIC ACTIVITY Reaction=prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O; Xref=Rhea:RHEA:51692, ChEBI:CHEBI:15377, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934, ChEBI:CHEBI:59789, ChEBI:CHEBI:134278;
case <OC:Pseudomonadota>
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.

Keywords [?]

Gene Ontology [?]

GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity
GO:1904047; Molecular function:S-adenosyl-L-methionine binding

Cross-references [?]

Pfam PF08241; Methyltransf_11; 1;
Pfam PF08242; Methyltransf_12; 1;
PIRSF PIRSF006325; MeTrfase_bac; 1;
NCBIfam TIGR00740; TIGR00740; 1;

Features [?]

From: CMOA_ECOLI (P76290)
Key From To Description Tag Condition FTGroup
BINDING 64 66 /ligand="S-adenosyl-L-methionine"
BINDING 89 90 /ligand="S-adenosyl-L-methionine"
BINDING 117 118 /ligand="S-adenosyl-L-methionine"
BINDING 39 39 /ligand="S-adenosyl-L-methionine"
BINDING 132 132 /ligand="S-adenosyl-L-methionine"
BINDING 199 199 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 228-274 amino acids
Related rules None
Fusion Nter: None Cter: None

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