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HAMAP rule MF_01595

General rule information [?]

Accession	MF_01595
Dates	19-MAR-2008 (Created) 1-JUN-2023 (Last updated, Version 20)
Name	PNPase
Scope(s)	Bacteria
Template(s)	P05055 (PNP_ECOLI); Q8ZLT3 (PNP_SALTY); P50849 (PNP_BACSU); Q53597 (PNP_STRAT); [ Recover all ]
Triggered by	HAMAP; MF_01595 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PNP
Protein name	RecName: Full=Polyribonucleotide nucleotidyltransferase; EC=2.7.7.8; AltName: Full=Polynucleotide phosphorylase; Short=PNPase;
Gene name	Name=pnp;

Comments [?]

FUNCTION	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
CATALYTIC ACTIVITY	Reaction=phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n); Xref=Rhea:RHEA:22096, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:140395; EC=2.7.7.8;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Gammaproteobacteria>
SUBUNIT	Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the polyribonucleotide nucleotidyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0004654; Molecular function:polyribonucleotide nucleotidyltransferase activity

GO:0000287; Molecular function:magnesium ion binding

GO:0003723; Molecular function:RNA binding

GO:0006402; Biological process:mRNA catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: PNP_ECOLI (P05055)

Key

From

Description

Tag

Condition

FTGroup

BINDING

486

/ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"

BINDING

492

/ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"

Additional information [?]