HAMAP rule MF_01595
General rule information
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Accession | MF_01595 |
Dates | 19-MAR-2008 (Created) 19-NOV-2022 (Last updated, Version 19) |
Name | PNPase |
Scope | Bacteria |
Templates | P05055 (PNP_ECOLI); Q8ZLT3 (PNP_SALTY); P50849 (PNP_BACSU); Q53597 (PNP_STRAT): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. |
Catalytic activity | RHEA:22096: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)
EC 2.7.7.8 |
Cofactor | Mg(2+) |
case <OC:Gammaproteobacteria>
Subunit | Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the polyribonucleotide nucleotidyltransferase family. |
Keywords
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Gene Ontology
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GO:0004654; Molecular function: polyribonucleotide nucleotidyltransferase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0003723; Molecular function: RNA binding.
GO:0006402; Biological process: mRNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0003723; Molecular function: RNA binding.
GO:0006402; Biological process: mRNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS50084; KH_TYPE_1; 1; trigger=PRU00117; |
PS50126; S1; 1; trigger=PRU00180; | |
Pfam | PF00013; KH_1; 1; |
PF03726; PNPase; 1; | |
PF01138; RNase_PH; 2; | |
PF03725; RNase_PH_C; 2; | |
PF00575; S1; 1; | |
PIRSF | PIRSF005499; PNPase; 1; |
TIGRFAMs | TIGR03591; Polynuc_phos; 1; |
TIGR02696; PppGpp_PNP; 1; |
Features
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From: PNP_ECOLI (P05055) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 486 | 486 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 492 | 492 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D |
Additional information
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Size range | 686-914 amino acids |
Related rules | None |
Fusion | None |