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HAMAP rule MF_01595

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General rule information [?]

Accession MF_01595
Dates 19-MAR-2008 (Created)
1-JUN-2023 (Last updated, Version 20)
Name PNPase
Scope(s) Bacteria
Template(s) P05055 (PNP_ECOLI); Q8ZLT3 (PNP_SALTY); P50849 (PNP_BACSU); Q53597 (PNP_STRAT); [ Recover all ]
Triggered by HAMAP; MF_01595 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PNP
Protein name RecName: Full=Polyribonucleotide nucleotidyltransferase;
AltName: Full=Polynucleotide phosphorylase;
Gene name Name=pnp;

Comments [?]

FUNCTIONInvolved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
CATALYTIC ACTIVITY Reaction=phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n); Xref=Rhea:RHEA:22096, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:140395; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Gammaproteobacteria>
SUBUNITComponent of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
end case
SIMILARITYBelongs to the polyribonucleotide nucleotidyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0004654; Molecular function:polyribonucleotide nucleotidyltransferase activity
GO:0000287; Molecular function:magnesium ion binding
GO:0003723; Molecular function:RNA binding
GO:0006402; Biological process:mRNA catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS50084; KH_TYPE_1; 1;
PROSITE PS50126; S1; 1;
Pfam PF00013; KH_1; 1;
Pfam PF03726; PNPase; 1;
Pfam PF01138; RNase_PH; 2;
Pfam PF03725; RNase_PH_C; 2;
Pfam PF00575; S1; 1;
PIRSF PIRSF005499; PNPase; 1;
NCBIfam TIGR03591; Polynuc_phos; 1;
NCBIfam TIGR02696; PppGpp_PNP; 1;

Features [?]

From: PNP_ECOLI (P05055)
Key From To Description Tag Condition FTGroup
BINDING 486 486 /ligand="Mg(2+)"
BINDING 492 492 /ligand="Mg(2+)"

Additional information [?]

Size range 686-914 amino acids
Related rules None
Fusion Nter: None Cter: None

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