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Annotation rule MF_01595 |
General rule information
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Accession |
MF_01595 |
Dates |
19-MAR-2008 (Created) 14-MAY-2022 (Last updated, Version 18) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Polyribonucleotide nucleotidyltransferase;
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EC 2.7.7.8;
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AltName:
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Full=Polynucleotide phosphorylase;
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Short=PNPase;
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Function |
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. |
Catalytic activity |
RHEA:22096: phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)
EC 2.7.7.8
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Cofactor |
Mg(2+) |
case <OC:Gammaproteobacteria>
Subunit |
Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the polyribonucleotide nucleotidyltransferase family. |
GO:0004654; Molecular function: polyribonucleotide nucleotidyltransferase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0003723; Molecular function: RNA binding.
GO:0006402; Biological process: mRNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
From: PNP_ECOLI (P05055) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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486
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486
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/ligand="Mg(2+)" /ligand_id="18420
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D
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BINDING
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492
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492
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/ligand="Mg(2+)" /ligand_id="18420
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D
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Additional information
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Size range |
686-914 amino acids |
Related rules |
None |
Fusion |
None |