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HAMAP rule MF_01596

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General rule information [?]

Accession MF_01596
Dates 20-MAR-2008 (Created)
19-NOV-2019 (Last updated, Version 11)
Name MgrB
Scope(s) Bacteria
Template(s) P64512 (MGRB_ECOLI); D0ZK39 (MGRB_SALT1); P0DM79 (MGRB_YERPE); [ Recover all ]
Triggered by HAMAP; MF_01596 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MGRB
Protein name RecName: Full=PhoP/PhoQ regulator MgrB;
Gene name Name=mgrB;

Comments [?]

FUNCTIONPhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
SUBUNITMay form homooligomers. Probably interacts with the periplasmic domain of PhoQ.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the MgrB family.

Keywords [?]

Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case

Gene Ontology [?]

GO:0070298; Biological process:negative regulation of phosphorelay signal transduction system
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

General Transmembrane; -; 1;

Features [?]

Additional information [?]

Size range 46-50 amino acids
Related rules None
Fusion Nter: None Cter: None

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