HAMAP rule MF_01596
General rule information
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| Accession | MF_01596 |
| Dates | 20-MAR-2008 (Created) 19-NOV-2019 (Last updated, Version 11) |
| Name | MgrB |
| Scope | Bacteria; Enterobacterales |
| Templates | P64512 (MGRB_ECOLI); D0ZK39 (MGRB_SALT1); P0DM79 (MGRB_YERPE): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. |
| Subunit | May form homooligomers. Probably interacts with the periplasmic domain of PhoQ. |
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Single-pass membrane protein. |
end case
| Similarity | Belongs to the MgrB family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0070298; Biological process: negative regulation of phosphorelay signal transduction system.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Computed features
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| General | Transmembrane; -; 1; trigger=yes; |
Additional information
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| Size range | 46-50 amino acids |
| Related rules | None |
| Fusion | None |