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HAMAP rule MF_01601

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General rule information [?]

Accession MF_01601
Dates 25-OCT-2004 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Heptose_epimerase
Scope(s) Bacteria
Template(s) P67910 (HLDD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01601 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HLDD
Protein name RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
                 EC=5.1.3.20;
AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
                 Short=ADP-glyceromanno-heptose 6-epimerase;
                 Short=ADP-hep 6-epimerase;
                 Short=AGME;
Gene name Name=hldD;

Comments [?]

FUNCTIONCatalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
CATALYTIC ACTIVITY Reaction=ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D- manno-heptose; Xref=Rhea:RHEA:17577, ChEBI:CHEBI:59967, ChEBI:CHEBI:61506; EC=5.1.3.20;
COFACTOR Name=NADP(+); Xref=ChEBI:CHEBI:58349; Note=Binds 1 NADP(+) per subunit.;
PATHWAYNucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
SUBUNITHomopentamer.
DOMAINContains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
SIMILARITYBelongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.

Keywords [?]

case <FT:18>
Acetylation
end case
Carbohydrate metabolism
Isomerase
NADP

Gene Ontology [?]

GO:0008712; Molecular function:ADP-glyceromanno-heptose 6-epimerase activity
GO:0005975; Biological process:carbohydrate metabolic process

Cross-references [?]

Pfam PF01370; Epimerase; 1;
NCBIfam TIGR02197; heptose_epim; 1;

Features [?]

From: HLDD_ECOLI (P67910)
Key From To Description Tag Condition FTGroup
BINDING 10 11 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
BINDING 31 32 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
BINDING 75 79 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
BINDING 201 204 /ligand="substrate"
ACT_SITE 140 140 /note="Proton acceptor" Y
ACT_SITE 178 178 /note="Proton acceptor" K
BINDING 38 38 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 [KQR]
BINDING 53 53 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 [KQR]
BINDING 92 92 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 N
BINDING 144 144 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 K
BINDING 169 169 /ligand="substrate" N
BINDING 170 170 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 [VI]
BINDING 178 178 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"		 K
BINDING 180 180 /ligand="substrate" x
BINDING 187 187 /ligand="substrate" [HKQ]
BINDING 209 209 /ligand="substrate" [HR]
BINDING 272 272 /ligand="substrate" Y
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 267 267 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 291-340 amino acids
Related rules None
Fusion Nter: None Cter: None



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