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Annotation rule MF_01601
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General rule information [?]

Accession MF_01601
Dates 25-OCT-2004 (Created)
19-NOV-2019 (Last updated, Version 23)
Name Heptose_epimerase
Scope
Bacteria
Template P67910 (HLDD_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HLDD
Protein name
RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
EC 5.1.3.20;
AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
Short=ADP-glyceromanno-heptose 6-epimerase;
Short=ADP-hep 6-epimerase;
Short=AGME;
Gene name
hldD

Comments [?]

Function Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity RHEA:17577: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
EC 5.1.3.20
Cofactor NADP(+)
Note: Binds 1 NADP(+) per subunit.
Pathway Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Subunit Homopentamer.
Domain Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
Similarity Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.

Keywords [?]

case <FT:18>
Acetylation
end case
Carbohydrate metabolism
Isomerase
NADP

Gene Ontology [?]

GO:0008712; Molecular function: ADP-glyceromanno-heptose 6-epimerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

Pfam PF01370; Epimerase; 1;
TIGRFAMs TIGR02197; heptose_epim; 1;

Features [?]

From: HLDD_ECOLI (P67910)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     11       NADP        
NP_BIND     31     32       NADP        
NP_BIND     75     79       NADP        
REGION     201     204       Substrate binding        
ACT_SITE     140     140       Proton acceptor     Y  
ACT_SITE     178     178       Proton acceptor     K  
BINDING     38     38       NADP     [KQR]  
BINDING     53     53       NADP     [KQR]  
BINDING     92     92       NADP     N  
BINDING     144     144       NADP     K  
BINDING     169     169       Substrate     N  
BINDING     170     170       NADP; via amide nitrogen     [VI]  
BINDING     178     178       NADP     K  
BINDING     180     180       Substrate; via carbonyl oxygen     x  
BINDING     187     187       Substrate     [HKQ]  
BINDING     209     209       Substrate     [HR]  
BINDING     272     272       Substrate     Y  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     267     267       N6-acetyllysine     K  
end case

Additional information [?]

Size range 291-340 amino acids
Related rules None
Fusion None


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