HAMAP rule MF_01601
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01601 |
| Accession | MF_01601 |
| Dates | 28-FEB-2005 (Created)
01-JUN-2023 (Last updated, Version 28) |
| Name | Heptose_epimerase |
| Scope(s) |
Bacteria |
| Template(s) | P67910; [ Recover all ] |
| Triggered by |
HAMAP; MF_01601 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HLDD |
| Protein name | RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase; EC=5.1.3.20; AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase; Short=ADP-glyceromanno-heptose 6-epimerase; Short=ADP-hep 6-epimerase; Short=AGME; |
| Gene name | Name=hldD; |
Comments
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| FUNCTION | Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. |
| CATALYTIC ACTIVITY | Reaction=ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D- manno-heptose; Xref=Rhea:RHEA:17577, ChEBI:CHEBI:59967, ChEBI:CHEBI:61506; EC=5.1.3.20; |
| COFACTOR | Name=NADP(+); Xref=ChEBI:CHEBI:58349; Note=Binds 1 NADP(+) per subunit.; |
| PATHWAY | Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 4/4. |
| SUBUNIT | Homopentamer. |
| DOMAIN | Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. |
| SIMILARITY | Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. |
Keywords
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| case <FT:18> | |
| Acetylation | |
| end case | |
| Carbohydrate metabolism | |
| Isomerase | |
| NADP | |
Gene Ontology
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| GO:0008712; Molecular function:ADP-glyceromanno-heptose 6-epimerase activity |
| GO:0005975; Biological process:carbohydrate metabolic process |
Cross-references
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Features
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| From: HLDD_ECOLI (P67910) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 11 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
|||||||||
| BINDING | 31 | 32 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
|||||||||
| BINDING | 75 | 79 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
|||||||||
| BINDING | 201 | 204 | /ligand="substrate" | |||||||||
| ACT_SITE | 140 | 140 | /note="Proton acceptor" | Y | ||||||||
| ACT_SITE | 178 | 178 | /note="Proton acceptor" | K | ||||||||
| BINDING | 38 | 38 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[KQR] | ||||||||
| BINDING | 53 | 53 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[KQR] | ||||||||
| BINDING | 92 | 92 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
N | ||||||||
| BINDING | 144 | 144 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
| BINDING | 169 | 169 | /ligand="substrate" | N | ||||||||
| BINDING | 170 | 170 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[VI] | ||||||||
| BINDING | 178 | 178 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
| BINDING | 180 | 180 | /ligand="substrate" | x | ||||||||
| BINDING | 187 | 187 | /ligand="substrate" | [HKQ] | ||||||||
| BINDING | 209 | 209 | /ligand="substrate" | [HR] | ||||||||
| BINDING | 272 | 272 | /ligand="substrate" | Y | ||||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 267 | 267 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 291-340 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |