HAMAP rule MF_01601
General rule information
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Accession | MF_01601 |
Dates | 25-OCT-2004 (Created) 1-JUN-2023 (Last updated, Version 27) |
Name | Heptose_epimerase |
Scope | Bacteria |
Template | P67910 (HLDD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. |
Catalytic activity | RHEA:17577: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
EC 5.1.3.20 |
Cofactor | NADP(+) Note: Binds 1 NADP(+) per subunit. |
Pathway | Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. |
Subunit | Homopentamer. |
Domain | Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. |
Similarity | Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. |
Keywords
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case <FT:18>
end case
Gene Ontology
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GO:0008712; Molecular function: ADP-glyceromanno-heptose 6-epimerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
Cross-references
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Features
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From: HLDD_ECOLI (P67910) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 10 | 11 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
BINDING | 31 | 32 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
BINDING | 75 | 79 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
BINDING | 201 | 204 | /ligand="substrate | |||||||||
ACT_SITE | 140 | 140 | Proton acceptor | Y | ||||||||
ACT_SITE | 178 | 178 | Proton acceptor | K | ||||||||
BINDING | 38 | 38 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [KQR] | ||||||||
BINDING | 53 | 53 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [KQR] | ||||||||
BINDING | 92 | 92 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | N | ||||||||
BINDING | 144 | 144 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | K | ||||||||
BINDING | 169 | 169 | /ligand="substrate | N | ||||||||
BINDING | 170 | 170 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [VI] | ||||||||
BINDING | 178 | 178 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | K | ||||||||
BINDING | 180 | 180 | /ligand="substrate | x | ||||||||
BINDING | 187 | 187 | /ligand="substrate | [HKQ] | ||||||||
BINDING | 209 | 209 | /ligand="substrate | [HR] | ||||||||
BINDING | 272 | 272 | /ligand="substrate | Y |
case <OC:Escherichia> or <OC:Shigella>
end case
Additional information
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Size range | 291-340 amino acids |
Related rules | None |
Fusion | None |