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Annotation rule MF_01601 |
General rule information
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Accession |
MF_01601 |
Dates |
25-OCT-2004 (Created) 19-NOV-2019 (Last updated, Version 23) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
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EC 5.1.3.20;
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AltName:
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Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
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Short=ADP-glyceromanno-heptose 6-epimerase;
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Short=ADP-hep 6-epimerase;
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Short=AGME;
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Function |
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. |
Catalytic activity |
RHEA:17577: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
EC 5.1.3.20
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Cofactor |
NADP(+) Note: Binds 1 NADP(+) per subunit. |
Pathway |
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. |
Subunit |
Homopentamer. |
Domain |
Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. |
Similarity |
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. |
case <FT:18>
end case
GO:0008712; Molecular function: ADP-glyceromanno-heptose 6-epimerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
From: HLDD_ECOLI (P67910) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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10
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11
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NADP
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NP_BIND
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31
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32
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NADP
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NP_BIND
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75
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79
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NADP
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REGION
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201
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204
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Substrate binding
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ACT_SITE
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140
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140
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Proton acceptor
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Y
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ACT_SITE
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178
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178
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Proton acceptor
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K
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BINDING
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38
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38
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NADP
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[KQR]
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BINDING
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53
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53
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NADP
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[KQR]
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BINDING
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92
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92
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NADP
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N
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BINDING
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144
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144
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NADP
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K
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BINDING
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169
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169
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Substrate
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N
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BINDING
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170
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170
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NADP; via amide nitrogen
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[VI]
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BINDING
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178
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178
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NADP
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K
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BINDING
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180
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180
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Substrate; via carbonyl oxygen
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x
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BINDING
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187
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187
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Substrate
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[HKQ]
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BINDING
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209
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209
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Substrate
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[HR]
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BINDING
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272
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272
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Substrate
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Y
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case <OC:Escherichia> or <OC:Shigella>
MOD_RES
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267
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267
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N6-acetyllysine
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K
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end case
Additional information
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Size range |
291-340 amino acids |
Related rules |
None |
Fusion |
None |