HAMAP rule MF_01601

General rule information [?]

Accession	MF_01601
Dates	25-OCT-2004 (Created) 1-JUN-2023 (Last updated, Version 27)

Name	Heptose_epimerase

Scope

Bacteria

Template

P67910 (HLDD_ECOLI)

Triggered by

HAMAP; MF_01601 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HLDD

Protein name

RecName:		Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
		EC 5.1.3.20;
AltName:		Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
		Short=ADP-glyceromanno-heptose 6-epimerase;
		Short=ADP-hep 6-epimerase;
		Short=AGME;

Gene name

hldD

Comments [?]

Function	Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity	RHEA:17577: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose EC 5.1.3.20
Cofactor	NADP(+) Note: Binds 1 NADP(+) per subunit.
Pathway	Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Subunit	Homopentamer.
Domain	Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
Similarity	Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.

Keywords [?]

case <FT:18>

Acetylation

end case

Carbohydrate metabolism
Isomerase
NADP

Gene Ontology [?]

GO:0008712; Molecular function: ADP-glyceromanno-heptose 6-epimerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

Pfam	PF01370; Epimerase; 1;
NCBIfam	TIGR02197; heptose_epim; 1;

Features [?]

From: HLDD_ECOLI (P67910)

Key From To Description Tag Condition FTGroup

BINDING 10 11 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349

BINDING 31 32 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349

BINDING 75 79 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349

BINDING 201 204 /ligand="substrate

ACT_SITE 140 140 Proton acceptor Y

ACT_SITE 178 178 Proton acceptor K

BINDING 38 38 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [KQR]

BINDING 53 53 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [KQR]

BINDING 92 92 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 N

BINDING 144 144 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 K

BINDING 169 169 /ligand="substrate N

BINDING 170 170 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [VI]

BINDING 178 178 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 K

BINDING 180 180 /ligand="substrate x

BINDING 187 187 /ligand="substrate [HKQ]

BINDING 209 209 /ligand="substrate [HR]

BINDING 272 272 /ligand="substrate Y

case <OC:Escherichia> or <OC:Shigella>

MOD_RES 267 267 N6-acetyllysine K

end case

Additional information [?]

Size range	291-340 amino acids
Related rules	None
Fusion	None

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