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HAMAP rule MF_01601

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General rule information [?]

Accession MF_01601
Dates 25-OCT-2004 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Heptose_epimerase
Template P67910 (HLDD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
Short=ADP-glyceromanno-heptose 6-epimerase;
Short=ADP-hep 6-epimerase;
Gene name

Comments [?]

Function Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity RHEA:17577: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
Cofactor NADP(+)
Note: Binds 1 NADP(+) per subunit.
Pathway Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Subunit Homopentamer.
Domain Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
Similarity Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.

Keywords [?]

case <FT:18>
end case

Gene Ontology [?]

GO:0008712; Molecular function: ADP-glyceromanno-heptose 6-epimerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

Pfam PF01370; Epimerase; 1;
NCBIfam TIGR02197; heptose_epim; 1;

Features [?]

From: HLDD_ECOLI (P67910)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     10     11       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349        
BINDING     31     32       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349        
BINDING     75     79       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349        
BINDING     201     204       /ligand="substrate        
ACT_SITE     140     140       Proton acceptor     Y  
ACT_SITE     178     178       Proton acceptor     K  
BINDING     38     38       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     [KQR]  
BINDING     53     53       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     [KQR]  
BINDING     92     92       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     N  
BINDING     144     144       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     K  
BINDING     169     169       /ligand="substrate     N  
BINDING     170     170       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     [VI]  
BINDING     178     178       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     K  
BINDING     180     180       /ligand="substrate     x  
BINDING     187     187       /ligand="substrate     [HKQ]  
BINDING     209     209       /ligand="substrate     [HR]  
BINDING     272     272       /ligand="substrate     Y  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     267     267       N6-acetyllysine     K  
end case

Additional information [?]

Size range 291-340 amino acids
Related rules None
Fusion None