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HAMAP rule MF_01608

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General rule information [?]

Accession MF_01608
Dates 18-FEB-2005 (Created)
28-JUL-2023 (Last updated, Version 28)
Name CoA_diS_reduct
Scope(s) Bacteria
Template(s) O52582 (CDR_STAA8); [ Recover all ]
Triggered by HAMAP; MF_01608 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CDR
Protein name RecName: Full=Coenzyme A disulfide reductase;
                 Short=CoA-disulfide reductase;
Gene name Name=cdr;

Comments [?]

FUNCTIONCatalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide.
CATALYTIC ACTIVITY Reaction=2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:14705, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62209; EC=;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
DOMAINContains 2 FAD binding domains and a single NADPH binding domain.
MISCELLANEOUSReduction of disulfides occurs by a thiol-disulfide exchange reaction, but involves only a single catalytic cysteine residue that forms a stable mixed disulfide with CoA during catalysis.
SIMILARITYBelongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Keywords [?]

Gene Ontology [?]

GO:0050451; Molecular function:CoA-disulfide reductase (NADP) activity
GO:0050660; Molecular function:flavin adenine dinucleotide binding
GO:0050661; Molecular function:NADP binding
GO:0003756; Molecular function:protein disulfide isomerase activity

Cross-references [?]

Pfam PF07992; Pyr_redox_2; 1;
Pfam PF02852; Pyr_redox_dim; 1;
NCBIfam TIGR03385; CoA_CoA_reduc; 1;

Features [?]

From: CDR_STAA8 (O52582)
Key From To Description Tag Condition FTGroup
BINDING 8 33 /ligand="FAD"
BINDING 151 166 /ligand="NADP(+)"
BINDING 267 277 /ligand="FAD"
ACT_SITE 43 43 /note="Nucleophile" C
ACT_SITE 43 43 /note="Redox-active" C
BINDING 15 15 /ligand="substrate" T
BINDING 19 19 /ligand="substrate" Q
BINDING 22 22 /ligand="substrate" R
BINDING 39 39 /ligand="substrate" S
BINDING 42 42 /ligand="substrate" N
BINDING 71 71 /ligand="substrate" K
BINDING 299 299 /ligand="substrate" H
BINDING 419 419 /ligand="FAD"
BINDING 427 427 /ligand="substrate" K

Additional information [?]

Size range 438-440 amino acids
Related rules None
Fusion Nter: None Cter: None

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