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HAMAP rule MF_01611

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General rule information [?]

Accession MF_01611
Dates 8-APR-2005 (Created)
1-JUN-2023 (Last updated, Version 26)
Name FO_synth_sub1
Scope(s) Bacteria
Template(s) Q57888 (COFG_METJA); [ Recover all ]
Triggered by HAMAP; MF_01611 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COFG
Protein name RecName: Full=7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase;
AltName: Full=FO synthase subunit 1;
Gene name Name=cofG;

Comments [?]

FUNCTIONCatalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
CATALYTIC ACTIVITY Reaction=5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6- dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8- didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+); Xref=Rhea:RHEA:55204, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:28938, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:59904, ChEBI:CHEBI:85936; EC=;
case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
PATHWAYCofactor biosynthesis; coenzyme F0 biosynthesis.
SUBUNITThe FO synthase complex consists of two subunits, CofG and CofH.
SIMILARITYBelongs to the radical SAM superfamily. CofG family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0016841; Molecular function:ammonia-lyase activity

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
NCBIfam TIGR03550; F420_cofG; 1;

Features [?]

From: COFG_METJA (Q57888)
Key From To Description Tag Condition FTGroup
BINDING 49 49 /ligand="[4Fe-4S] cluster"
C 1
BINDING 53 53 /ligand="[4Fe-4S] cluster"
C 1
BINDING 56 56 /ligand="[4Fe-4S] cluster"
C 1

Additional information [?]

Size range 313-380 amino acids
Related rules None
Fusion Nter: None Cter: MF_01612 (cofH)
Comments Euryarchaeota, cyanobacteria and actinomycetes are known to produce coenzyme FO. Euryarchaeota and actinomycetes use it to synthesize coenzyme F420, whereas cyanobacteria use it for FO-dependent DNA photolyases. In actinomycetes, the two subunits cofG and cofH are fused, and are called fbiC. Possible wrong starts.

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