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Annotation rule MF_01621 |
Accession | MF_01621 |
Dates | 18-NOV-2005 (Created) 16-NOV-2020 (Last updated, Version 30) |
Name | FadB |
Scope | Bacteria; Gammaproteobacteria |
Templates | P21177 (FADB_ECOLI); P28793 (FADB_PSEFR): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. |
Catalytic activity | RHEA:22432: a (3S)-3-hydroxy-fatty acyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH
EC 1.1.1.35 |
RHEA:16105: a (3S)-3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O
EC 4.2.1.17 |
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RHEA:20724: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
EC 4.2.1.17 |
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RHEA:21760: (3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA
EC 5.1.2.3 |
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RHEA:45900: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
EC 5.3.3.8 |
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RHEA:45228: a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
EC 5.3.3.8 |
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Pathway | Lipid metabolism; fatty acid beta-oxidation. |
Subunit | Heterotetramer of two alpha chains (FadB) and two beta chains (FadA). |
Similarity | In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. |
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. |
PROSITE | PS00067; 3HCDH; 1; |
PS00166; ENOYL_COA_HYDRATASE; 1; | |
Pfam | PF00725; 3HCDH; 1; |
PF02737; 3HCDH_N; 1; | |
PF00378; ECH; 1; | |
TIGRFAMs | TIGR02437; FadB; 1; |
From: FADB_PSEFR (P28793) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 401 | 403 | NAD | [VI]-[VT]-E | ||||||||
REGION | Nter | 190 | Enoyl-CoA hydratase/isomerase | |||||||||
REGION | 312 | Cter | 3-hydroxyacyl-CoA dehydrogenase | |||||||||
ACT_SITE | 451 | 451 | For 3-hydroxyacyl-CoA dehydrogenase activity | H | ||||||||
BINDING | 297 | 297 | Substrate | D | ||||||||
BINDING | 325 | 325 | NAD; via amide nitrogen | M | ||||||||
BINDING | 344 | 344 | NAD | D | ||||||||
BINDING | 408 | 408 | NAD | K | ||||||||
BINDING | 430 | 430 | NAD | S | ||||||||
BINDING | 454 | 454 | NAD | N | ||||||||
BINDING | 501 | 501 | Substrate | N | ||||||||
BINDING (Optional) | 660 | 660 | Substrate | Y | ||||||||
SITE | 120 | 120 | Important for catalytic activity | E | ||||||||
SITE | 140 | 140 | Important for catalytic activity | E |
Size range | 715-729 amino acids |
Related rules | None |
Fusion | None |