![]() |
|
Annotation rule MF_01622 |
Accession | MF_01622 |
Dates | 21-NOV-2005 (Created) 4-NOV-2020 (Last updated, Version 21) |
Name | tRNA_sel_U_synth |
Scope | Bacteria; Proteobacteria |
Templates | P33667 (SELU_ECOLI); Q8ZR88 (SELU_SALTY): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. |
Catalytic activity | RHEA:42716: (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate
EC 2.9.1.3 PhysiologicalDirection=left-to-right (RHEA:42717) |
Subunit | Monomer. |
Similarity | Belongs to the SelU family. |
From: SELU_ECOLI (P33667) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 97 | 97 | S-selanylcysteine intermediate | C |
Size range | 350-410 amino acids |
Related rules | None |
Fusion | None |