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Annotation rule MF_01622
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General rule information [?]

Accession MF_01622
Dates 21-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 20)
Name tRNA_sel_U_synth
Scope
Bacteria; Proteobacteria
Templates P33667 (SELU_ECOLI); Q8ZR88 (SELU_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SELU
Protein name
RecName: Full=tRNA 2-selenouridine synthase;
EC 2.5.1.-;
Gene name
selU

Comments [?]

Function Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
Catalytic activity RHEA:42716: (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate + thiogeraniol
PhysiologicalDirection=left-to-right (RHEA:42717)
Subunit Monomer.
Similarity Belongs to the SelU family.

Keywords [?]

Selenium
Transferase

Gene Ontology [?]

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0002098; Biological process: tRNA wobble uridine modification.

Cross-references [?]

PROSITE PS50206; RHODANESE_3; 1; trigger=PRU00173;
TIGRFAMs TIGR03167; TRNA_sel_U_synt; 1;

Features [?]

From: SELU_ECOLI (P33667)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     97     97       S-selanylcysteine intermediate     C  

Additional information [?]

Size range 350-410 amino acids
Related rules None
Fusion None


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