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Annotation rule MF_01627
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General rule information [?]

Accession MF_01627
Dates 13-DEC-2005 (Created)
8-OCT-2020 (Last updated, Version 18)
Name Pur_nucleosid_phosp
Bacteria; Firmicutes
Bacteria; Proteobacteria
Templates P0ABP8 (DEOD_ECOLI); Q8ZJV7 (DEOD_SALTY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Purine nucleoside phosphorylase DeoD-type;
Gene name

Comments [?]

Function Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Catalytic activity RHEA:19805: a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate
RHEA:36431: a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase
Subunit Homohexamer; trimer of homodimers.
Similarity Belongs to the PNP/UDP phosphorylase family.

Keywords [?]

case <FTTag:acetylation>
end case

Gene Ontology [?]

GO:0004731; Molecular function: purine-nucleoside phosphorylase activity.
GO:0042278; Biological process: purine nucleoside metabolic process.

Cross-references [?]

PROSITE PS01232; PNP_UDP_1; 1;
Pfam PF01048; PNP_UDP_1; 1;
TIGRFAMs TIGR00107; deoD; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     205     205       Proton donor     D  
SITE     218     218       Important for catalytic activity     R  
REGION     88     91       Phosphate binding     R-[IV]-G-[TS]  
REGION     180     182       Purine nucleoside binding     [ED]-M-E  
REGION     204     205       Purine nucleoside binding     [ST]-[DN]  
BINDING     5     5       Purine nucleoside; shared with dimeric partner     H  
BINDING     21     21       Phosphate; via amide nitrogen     G  
BINDING     25     25       Phosphate     R  
BINDING     44     44       Phosphate; shared with dimeric partner     R  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     27     27       N6-acetyllysine   acetylation   K  
end case

Additional information [?]

Size range 220-270 amino acids
Related rules None
Fusion None