HAMAP rule MF_01628
General rule information
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Accession | MF_01628 |
Dates | 14-DEC-2005 (Created)
1-JUN-2023 (Last updated, Version 17) |
Name | Thymid_phosp |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P07650 (TYPH_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01628 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TYPH |
Protein name | RecName: Full=Thymidine phosphorylase; EC=2.4.2.4; AltName: Full=TdRPase; |
Gene name | Name=deoA; |
Comments
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FUNCTION | The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. |
CATALYTIC ACTIVITY | Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4; |
PATHWAY | Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. |
Keywords
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Gene Ontology
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GO:0009032; Molecular function:thymidine phosphorylase activity |
GO:0046104; Biological process:thymidine metabolic process |
Cross-references
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PROSITE | PS00647; THYMID_PHOSPHORYLASE; 1; |
Pfam | PF02885; Glycos_trans_3N; 1; |
Pfam | PF00591; Glycos_transf_3; 1; |
NCBIfam | TIGR02643; T_phosphoryl; 1; |
Features
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Additional information
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Size range | 438-448 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |