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| Annotation rule MF_01628 |
General rule information
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| Accession | MF_01628 |
| Dates | 14-DEC-2005 (Created) 19-NOV-2019 (Last updated, Version 15) |
| Name | Thymid_phosp |
| Scope | Bacteria; Proteobacteria |
| Template | P07650 (TYPH_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. |
| Catalytic activity | RHEA:16037: phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
EC 2.4.2.4 |
| Pathway | Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. |
| Subunit | Homodimer. |
| Similarity | Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. |
Keywords
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Gene Ontology
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GO:0009032; Molecular function: thymidine phosphorylase activity.
GO:0046104; Biological process: thymidine metabolic process.
GO:0046104; Biological process: thymidine metabolic process.
Cross-references
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| PROSITE | PS00647; THYMID_PHOSPHORYLASE; 1; |
| Pfam | PF02885; Glycos_trans_3N; 1; |
| PF00591; Glycos_transf_3; 1; | |
| TIGRFAMs | TIGR02643; T_phosphoryl; 1; |
Additional information
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| Size range | 438-448 amino acids |
| Related rules | None |
| Fusion | None |