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HAMAP rule MF_01628

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General rule information [?]

Accession MF_01628
Dates 14-DEC-2005 (Created)
1-JUN-2023 (Last updated, Version 17)
Name Thymid_phosp
Scope(s) Bacteria
Template(s) P07650 (TYPH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01628 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TYPH
Protein name RecName: Full=Thymidine phosphorylase;
AltName: Full=TdRPase;
Gene name Name=deoA;

Comments [?]

FUNCTIONThe enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
CATALYTIC ACTIVITY Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=;
PATHWAYPyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
SIMILARITYBelongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Keywords [?]

Gene Ontology [?]

GO:0009032; Molecular function:thymidine phosphorylase activity
GO:0046104; Biological process:thymidine metabolic process

Cross-references [?]

Pfam PF02885; Glycos_trans_3N; 1;
Pfam PF00591; Glycos_transf_3; 1;
NCBIfam TIGR02643; T_phosphoryl; 1;

Features [?]

Additional information [?]

Size range 438-448 amino acids
Related rules None
Fusion Nter: None Cter: None

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