HAMAP rule MF_01628

General rule information [?]

Accession	MF_01628
Dates	14-DEC-2005 (Created) 1-JUN-2023 (Last updated, Version 17)
Name	Thymid_phosp
Scope(s)	Bacteria Pseudomonadota
Template(s)	P07650 (TYPH_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01628 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TYPH
Protein name	RecName: Full=Thymidine phosphorylase; EC=2.4.2.4; AltName: Full=TdRPase;
Gene name	Name=deoA;

Comments [?]

FUNCTION	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
CATALYTIC ACTIVITY	Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
PATHWAY	Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Keywords [?]

Gene Ontology [?]

GO:0009032; Molecular function:thymidine phosphorylase activity

GO:0046104; Biological process:thymidine metabolic process

Cross-references [?]

Features [?]

Additional information [?]