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Annotation rule MF_01636
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General rule information [?]

Accession MF_01636
Dates 15-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 24)
Name UbiD
Scope
Bacteria; Proteobacteria
Template P0AAB4 (UBID_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UBID
Protein name
RecName: Full=3-octaprenyl-4-hydroxybenzoate carboxy-lyase;
EC 4.1.1.98;
AltName: Full=Polyprenyl p-hydroxybenzoate decarboxylase;
Gene name
ubiD

Comments [?]

Function Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Catalytic activity RHEA:41680: a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2
EC 4.1.1.98
Cofactor prenyl-FMN
Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
Mn(2+)
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Subunit Homohexamer.
Subcellular location Cell membrane; Peripheral membrane protein.
Similarity Belongs to the UbiD family.

Keywords [?]

Decarboxylase
Lyase
Manganese
Membrane
Metal-binding
Cell membrane
Ubiquinone biosynthesis
Flavoprotein
FMN

Gene Ontology [?]

GO:0008694; Molecular function: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01977; UbiD; 1;
TIGRFAMs TIGR00148; TIGR00148; 1;

Features [?]

From: UBID_ECOLI (P0AAB4)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     178     180       Prenyl-FMN binding     [IV]-Y-R  
REGION     192     194       Prenyl-FMN binding     R-W-L  
REGION     197     198       Prenyl-FMN binding     R-G  
ACT_SITE     290     290       Proton donor     D  
METAL     175     175       Manganese     N  
METAL     241     241       Manganese     E  

Additional information [?]

Size range 487-522 amino acids
Related rules None
Fusion None


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