HAMAP rule MF_01636

General rule information [?]

Accession	MF_01636
Dates	15-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 29)

Name

UbiD

Scope

Bacteria; Pseudomonadota

Template

P0AAB4 (UBID_ECOLI)

Triggered by

HAMAP; MF_01636 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

UBID

Protein name

RecName:		Full=3-octaprenyl-4-hydroxybenzoate carboxy-lyase;
		EC 4.1.1.98;
AltName:		Full=Polyprenyl p-hydroxybenzoate decarboxylase;

Gene name

ubiD

Comments [?]

Function	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Catalytic activity	RHEA:41680: a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2 EC 4.1.1.98
Cofactor	prenyl-FMN Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
	Mn(2+)
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Subunit	Homohexamer.
Subcellular location	Cell membrane; Peripheral membrane protein.
Similarity	Belongs to the UbiD family.

Keywords [?]

Decarboxylase
Lyase
Manganese
Membrane
Metal-binding
Cell membrane
Ubiquinone biosynthesis
Flavoprotein
FMN

Gene Ontology [?]

GO:0008694; Molecular function: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF01977; UbiD; 1;
NCBIfam	TIGR00148; TIGR00148; 1;

Features [?]

From: UBID_ECOLI (P0AAB4)

Key From To Description Tag Condition FTGroup

BINDING 178 180 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 [IV]-Y-R

BINDING 192 194 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 R-W-L

BINDING 197 198 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 R-G

ACT_SITE 290 290 Proton donor D

BINDING 175 175 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 N

BINDING 241 241 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 E

Additional information [?]

Size range	487-522 amino acids
Related rules	None
Fusion	None

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