HAMAP rule MF_01636
General rule information
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| Accession | MF_01636 |
| Dates | 15-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | UbiD |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0AAB4 (UBID_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01636 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UBID |
| Protein name | RecName: Full=3-octaprenyl-4-hydroxybenzoate carboxy-lyase; EC=4.1.1.98; AltName: Full=Polyprenyl p-hydroxybenzoate decarboxylase; |
| Gene name | Name=ubiD; |
Comments
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| FUNCTION | Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all- trans-polyprenylphenol + CO2; Xref=Rhea:RHEA:41680, Rhea:RHEA- COMP:9514, Rhea:RHEA-COMP:9516, ChEBI:CHEBI:1269, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:78396; EC=4.1.1.98; |
| COFACTOR | Name=prenyl-FMN; Xref=ChEBI:CHEBI:87746; Note=Binds 1 prenylated FMN (prenyl-FMN) per subunit.; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| SUBUNIT | Homohexamer. |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| SIMILARITY | Belongs to the UbiD family. |
Keywords
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| Decarboxylase |
| Lyase |
| Manganese |
| Membrane |
| Metal-binding |
| Cell membrane |
| Ubiquinone biosynthesis |
| Flavoprotein |
| FMN |
Gene Ontology
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| GO:0008694; Molecular function:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity |
| GO:0006744; Biological process:ubiquinone biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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| From: UBID_ECOLI (P0AAB4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 178 | 180 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
[IV]-Y-R | ||||||||
| BINDING | 192 | 194 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
R-W-L | ||||||||
| BINDING | 197 | 198 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
R-G | ||||||||
| ACT_SITE | 290 | 290 | /note="Proton donor" | D | ||||||||
| BINDING | 175 | 175 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
N | ||||||||
| BINDING | 241 | 241 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | ||||||||
Additional information
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| Size range | 487-522 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |