HAMAP rule MF_01636
General rule information
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Accession | MF_01636 |
Dates | 15-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 29) |
Name | UbiD |
Scope | Bacteria; Pseudomonadota |
Template | P0AAB4 (UBID_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. |
Catalytic activity | RHEA:41680: a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2
EC 4.1.1.98 |
Cofactor | prenyl-FMN Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit. |
Mn(2+) | |
Pathway | Cofactor biosynthesis; ubiquinone biosynthesis. |
Subunit | Homohexamer. |
Subcellular location | Cell membrane; Peripheral membrane protein. |
Similarity | Belongs to the UbiD family. |
Keywords
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Decarboxylase
Lyase
Manganese
Membrane
Metal-binding
Cell membrane
Ubiquinone biosynthesis
Flavoprotein
FMN
Lyase
Manganese
Membrane
Metal-binding
Cell membrane
Ubiquinone biosynthesis
Flavoprotein
FMN
Gene Ontology
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GO:0008694; Molecular function: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Features
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From: UBID_ECOLI (P0AAB4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 178 | 180 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 | [IV]-Y-R | ||||||||
BINDING | 192 | 194 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 | R-W-L | ||||||||
BINDING | 197 | 198 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 | R-G | ||||||||
ACT_SITE | 290 | 290 | Proton donor | D | ||||||||
BINDING | 175 | 175 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | N | ||||||||
BINDING | 241 | 241 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | E |
Additional information
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Size range | 487-522 amino acids |
Related rules | None |
Fusion | None |