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HAMAP rule MF_01636

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General rule information [?]

Accession MF_01636
Dates 15-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 29)
Name UbiD
Scope(s) Bacteria
Template(s) P0AAB4 (UBID_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01636 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UBID
Protein name RecName: Full=3-octaprenyl-4-hydroxybenzoate carboxy-lyase;
AltName: Full=Polyprenyl p-hydroxybenzoate decarboxylase;
Gene name Name=ubiD;

Comments [?]

FUNCTIONCatalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
CATALYTIC ACTIVITY Reaction=a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all- trans-polyprenylphenol + CO2; Xref=Rhea:RHEA:41680, Rhea:RHEA- COMP:9514, Rhea:RHEA-COMP:9516, ChEBI:CHEBI:1269, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:78396; EC=;
COFACTOR Name=prenyl-FMN; Xref=ChEBI:CHEBI:87746; Note=Binds 1 prenylated FMN (prenyl-FMN) per subunit.;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
SIMILARITYBelongs to the UbiD family.

Keywords [?]

Gene Ontology [?]

GO:0008694; Molecular function:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO:0006744; Biological process:ubiquinone biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01977; UbiD; 1;
NCBIfam TIGR00148; TIGR00148; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 178 180 /ligand="prenyl-FMN"
BINDING 192 194 /ligand="prenyl-FMN"
BINDING 197 198 /ligand="prenyl-FMN"
ACT_SITE 290 290 /note="Proton donor" D
BINDING 175 175 /ligand="Mn(2+)"
BINDING 241 241 /ligand="Mn(2+)"

Additional information [?]

Size range 487-522 amino acids
Related rules None
Fusion Nter: None Cter: None

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