HAMAP rule MF_01638

General rule information [?]

Accession	MF_01638
Dates	23-NOV-2006 (Created) 26-JAN-2023 (Last updated, Version 19)

Name

PdxK

Scope

Bacteria; Pseudomonadota

Template

P40191 (PDXK_ECOLI)

Triggered by

HAMAP; MF_01638 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PDXK

Protein name

RecName:		Full=Pyridoxine/pyridoxal/pyridoxamine kinase;
		Short=PN/PL/PM kinase;
		EC 2.7.1.35;
AltName:		Full=B6-vitamer kinase;

Gene name

pdxK

Comments [?]

Function	B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
Catalytic activity	RHEA:10224: ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate EC 2.7.1.35
	RHEA:25108: ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate
	RHEA:25104: ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate
Cofactor	Mg(2+)
Pathway	Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.
	Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.
	Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.
Subunit	Homodimer.
Similarity	Belongs to the pyridoxine kinase family. PdxK subfamily.

Keywords [?]

ATP-binding
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase
Zinc

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0008478; Molecular function: pyridoxal kinase activity.
GO:0009443; Biological process: pyridoxal 5'-phosphate salvage.

Cross-references [?]

Pfam	PF08543; Phos_pyr_kin; 1;
TIGRFAMs	TIGR00687; pyridox_kin; 1;

Features [?]

From: PDXK_ECOLI (P40191)

Key From To Description Tag Condition FTGroup

BINDING 221 224 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 H-x-x-[VI]

BINDING 136 136 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 Y

BINDING 162 162 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 23 23 /ligand="substrate S

BINDING 59 59 /ligand="substrate H

BINDING 125 125 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D

BINDING 157 157 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 T

BINDING 162 162 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 E

BINDING 195 195 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 T

BINDING 231 231 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 T

BINDING 233 233 /ligand="substrate D

Additional information [?]

Size range	283-296 amino acids
Related rules	None
Fusion	None

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