HAMAP rule MF_01638
General rule information
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Accession | MF_01638 |
Dates | 23-NOV-2006 (Created) 26-JAN-2023 (Last updated, Version 19) |
Name | PdxK |
Scope | Bacteria; Pseudomonadota |
Template | P40191 (PDXK_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. |
Catalytic activity | RHEA:10224: ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate
EC 2.7.1.35 |
RHEA:25108: ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate | |
RHEA:25104: ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate | |
Cofactor | Mg(2+) |
Pathway | Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. |
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. | |
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1. | |
Subunit | Homodimer. |
Similarity | Belongs to the pyridoxine kinase family. PdxK subfamily. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0008478; Molecular function: pyridoxal kinase activity.
GO:0009443; Biological process: pyridoxal 5'-phosphate salvage.
GO:0008270; Molecular function: zinc ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0008478; Molecular function: pyridoxal kinase activity.
GO:0009443; Biological process: pyridoxal 5'-phosphate salvage.
Cross-references
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Features
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From: PDXK_ECOLI (P40191) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 221 | 224 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | H-x-x-[VI] | ||||||||
BINDING | 136 | 136 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | Y | ||||||||
BINDING | 162 | 162 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | ||||||||
BINDING | 23 | 23 | /ligand="substrate | S | ||||||||
BINDING | 59 | 59 | /ligand="substrate | H | ||||||||
BINDING | 125 | 125 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | D | ||||||||
BINDING | 157 | 157 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | T | ||||||||
BINDING | 162 | 162 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | E | ||||||||
BINDING | 195 | 195 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | T | ||||||||
BINDING | 231 | 231 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | T | ||||||||
BINDING | 233 | 233 | /ligand="substrate | D |
Additional information
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Size range | 283-296 amino acids |
Related rules | None |
Fusion | None |