HAMAP rule MF_01638
General rule information
[?]
Accession | MF_01638 |
Dates | 23-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 20) |
Name | PdxK |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P40191 (PDXK_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01638 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | PDXK |
Protein name | RecName: Full=Pyridoxine/pyridoxal/pyridoxamine kinase; Short=PN/PL/PM kinase; EC=2.7.1.35; AltName: Full=B6-vitamer kinase; |
Gene name | Name=pdxK; |
Comments
[?]
FUNCTION | B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. |
CATALYTIC ACTIVITY | Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35; |
CATALYTIC ACTIVITY | Reaction=ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate; Xref=Rhea:RHEA:25108, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709, ChEBI:CHEBI:30616, ChEBI:CHEBI:58589, ChEBI:CHEBI:456216; |
CATALYTIC ACTIVITY | Reaction=ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate; Xref=Rhea:RHEA:25104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57761, ChEBI:CHEBI:58451, ChEBI:CHEBI:456216; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. |
PATHWAY | Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. |
PATHWAY | Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the pyridoxine kinase family. PdxK subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0000287; Molecular function:magnesium ion binding |
GO:0008270; Molecular function:zinc ion binding |
GO:0005524; Molecular function:ATP binding |
GO:0008478; Molecular function:pyridoxal kinase activity |
GO:0009443; Biological process:pyridoxal 5'-phosphate salvage |
Cross-references
[?]
Features
[?]
From: PDXK_ECOLI (P40191) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 221 | 224 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H-x-x-[VI] | ||||||||
BINDING | 136 | 136 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
Y | ||||||||
BINDING | 162 | 162 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
BINDING | 23 | 23 | /ligand="substrate" | S | ||||||||
BINDING | 59 | 59 | /ligand="substrate" | H | ||||||||
BINDING | 125 | 125 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
BINDING | 157 | 157 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
BINDING | 162 | 162 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
BINDING | 195 | 195 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
BINDING | 231 | 231 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
BINDING | 233 | 233 | /ligand="substrate" | D |
Additional information
[?]
Size range | 283-296 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |