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HAMAP rule MF_01638

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General rule information [?]

Accession MF_01638
Dates 23-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 20)
Name PdxK
Scope(s) Bacteria
Pseudomonadota
Template(s) P40191 (PDXK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01638 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PDXK
Protein name RecName: Full=Pyridoxine/pyridoxal/pyridoxamine kinase;
                 Short=PN/PL/PM kinase;
                 EC=2.7.1.35;
AltName: Full=B6-vitamer kinase;
Gene name Name=pdxK;

Comments [?]

FUNCTIONB6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
CATALYTIC ACTIVITY Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35;
CATALYTIC ACTIVITY Reaction=ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate; Xref=Rhea:RHEA:25108, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709, ChEBI:CHEBI:30616, ChEBI:CHEBI:58589, ChEBI:CHEBI:456216;
CATALYTIC ACTIVITY Reaction=ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate; Xref=Rhea:RHEA:25104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57761, ChEBI:CHEBI:58451, ChEBI:CHEBI:456216;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYCofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.
PATHWAYCofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.
PATHWAYCofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.
SUBUNITHomodimer.
SIMILARITYBelongs to the pyridoxine kinase family. PdxK subfamily.

Keywords [?]

ATP-binding
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase
Zinc

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0008270; Molecular function:zinc ion binding
GO:0005524; Molecular function:ATP binding
GO:0008478; Molecular function:pyridoxal kinase activity
GO:0009443; Biological process:pyridoxal 5'-phosphate salvage

Cross-references [?]

Pfam PF08543; Phos_pyr_kin; 1;
NCBIfam TIGR00687; pyridox_kin; 1;

Features [?]

From: PDXK_ECOLI (P40191)
Key From To Description Tag Condition FTGroup
BINDING 221 224 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 H-x-x-[VI]
BINDING 136 136 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 Y
BINDING 162 162 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 E
BINDING 23 23 /ligand="substrate" S
BINDING 59 59 /ligand="substrate" H
BINDING 125 125 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 D
BINDING 157 157 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 T
BINDING 162 162 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 E
BINDING 195 195 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 T
BINDING 231 231 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 T
BINDING 233 233 /ligand="substrate" D

Additional information [?]

Size range 283-296 amino acids
Related rules None
Fusion Nter: None Cter: None



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