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Annotation rule MF_01638
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General rule information [?]

Accession MF_01638
Dates 23-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 16)
Name PdxK
Scope
Bacteria; Proteobacteria
Template P40191 (PDXK_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PDXK
Protein name
RecName: Full=Pyridoxine/pyridoxal/pyridoxamine kinase;
Short=PN/PL/PM kinase;
EC 2.7.1.35;
AltName: Full=B6-vitamer kinase;
Gene name
pdxK

Comments [?]

Function B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
Catalytic activity RHEA:10224: ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate
EC 2.7.1.35
RHEA:25108: ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate
RHEA:25104: ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate
Cofactor Mg(2+)
Pathway Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.
Subunit Homodimer.
Similarity Belongs to the pyridoxine kinase family. PdxK subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0008478; Molecular function: pyridoxal kinase activity.
GO:0009443; Biological process: pyridoxal 5'-phosphate salvage.

Cross-references [?]

Pfam PF08543; Phos_pyr_kin; 1;
TIGRFAMs TIGR00687; pyridox_kin; 1;

Features [?]

From: PDXK_ECOLI (P40191)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     221     224       ATP     H-x-x-[VI]  
METAL     136     136       Magnesium     Y  
METAL     162     162       Magnesium     E  
BINDING     23     23       Substrate     S  
BINDING     59     59       Substrate     H  
BINDING     125     125       ATP     D  
BINDING     157     157       ATP; via carbonyl oxygen     T  
BINDING     162     162       ATP     E  
BINDING     195     195       ATP     T  
BINDING     231     231       ATP     T  
BINDING     233     233       Substrate     D  

Additional information [?]

Size range 283-296 amino acids
Related rules None
Fusion None