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HAMAP rule MF_01639

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General rule information [?]

Accession MF_01639
Dates 29-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24)
Name PdxY
Scope(s) Bacteria
Template(s) P77150 (PDXY_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01639 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PDXY
Protein name RecName: Full=Pyridoxal kinase PdxY;
                 Short=PL kinase;
Gene name Name=pdxY;

Comments [?]

FUNCTIONPyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.
CATALYTIC ACTIVITY Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYCofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.
SIMILARITYBelongs to the pyridoxine kinase family. PdxY subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0005524; Molecular function:ATP binding
GO:0008478; Molecular function:pyridoxal kinase activity
GO:0009443; Biological process:pyridoxal 5'-phosphate salvage

Cross-references [?]

Pfam PF08543; Phos_pyr_kin; 1;
NCBIfam TIGR00687; pyridox_kin; 1;

Features [?]

From: PDXY_ECOLI (P77150)
Key From To Description Tag Condition FTGroup
BINDING 209 212 /ligand="ATP"
BINDING 45 46 /ligand="substrate" [TM]-Q
BINDING 10 10 /ligand="substrate" S
BINDING 112 112 /ligand="ATP"
BINDING 144 144 /ligand="ATP"
BINDING 149 149 /ligand="ATP"
BINDING 182 182 /ligand="ATP"
BINDING 224 224 /ligand="substrate" D

Additional information [?]

Size range 283-299 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments SALTI contains a C-terminal deletion removing the last 68 aa, and may therefore be non-functional. This sequence is not shown in alignment and was not taken into account for the size range field.

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