HAMAP rule MF_01644
General rule information
[?]
Accession |
MF_01644 |
Dates |
14-JAN-2008 (Created) 1-JUN-2023 (Last updated, Version 19) |
Scope |
Bacteria; Enterobacteriaceae |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=D-phenylhydantoinase;
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EC 3.5.2.-;
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AltName:
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Full=Hydantoin-utilizing enzyme HyuA;
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Function |
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown. |
Catalytic activity |
RHEA:51664: D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine
|
Cofactor |
a divalent metal cation Note: Binds 2 divalent metal cations per subunit. |
Subunit |
Homotetramer. |
Ptm |
Carboxylation allows a single lysine to coordinate two divalent metal cations. |
Similarity |
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. |
GO:0016812; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides.
From: PHYDA_ECOLI (Q46806) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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59
|
|
59
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
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|
|
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H
|
|
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BINDING
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61
|
|
61
|
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
|
|
|
|
H
|
|
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BINDING
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151
|
|
151
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" /note="via carbamate group
|
|
|
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K
|
|
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BINDING
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151
|
|
151
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" /note="via carbamate group
|
|
|
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K
|
|
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BINDING
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182
|
|
182
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2
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|
|
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H
|
|
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BINDING
|
|
239
|
|
239
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|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2
|
|
|
|
H
|
|
|
BINDING
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|
313
|
|
313
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/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
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|
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D
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BINDING
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156
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|
156
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/ligand="substrate
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|
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Y
|
|
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BINDING
|
|
286
|
|
286
|
|
/ligand="substrate
|
|
|
|
S
|
|
|
BINDING
|
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335
|
|
335
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/ligand="substrate
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|
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N
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MOD_RES
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151
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151
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N6-carboxylysine
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K
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Additional information
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Size range |
461-461 amino acids |
Related rules |
None |
Fusion |
None |