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Annotation rule MF_01644 |
Accession | MF_01644 |
Dates | 14-JAN-2008 (Created) 19-NOV-2019 (Last updated, Version 16) |
Name | D_hydantoinase |
Scope | Bacteria; Enterobacteriaceae |
Template | Q46806 (PHYDA_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown. |
Catalytic activity | RHEA:51664: D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine |
Cofactor | a divalent metal cation Note: Binds 2 divalent metal cations per subunit. |
Subunit | Homotetramer. |
Ptm | Carboxylation allows a single lysine to coordinate two divalent metal cations. |
Similarity | Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. |
From: PHYDA_ECOLI (Q46806) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 59 | 59 | Divalent metal cation 1 | H | ||||||||
METAL | 61 | 61 | Divalent metal cation 1 | H | ||||||||
METAL | 151 | 151 | Divalent metal cation 1; via carbamate group | K | ||||||||
METAL | 151 | 151 | Divalent metal cation 2; via carbamate group | K | ||||||||
METAL | 182 | 182 | Divalent metal cation 2 | H | ||||||||
METAL | 239 | 239 | Divalent metal cation 2 | H | ||||||||
METAL | 313 | 313 | Divalent metal cation 1 | D | ||||||||
BINDING | 156 | 156 | Substrate | Y | ||||||||
BINDING | 286 | 286 | Substrate; via amide nitrogen and carbonyl oxygen | S | ||||||||
BINDING | 335 | 335 | Substrate; via carbonyl oxygen | N | ||||||||
MOD_RES | 151 | 151 | N6-carboxylysine | K |
Size range | 461-461 amino acids |
Related rules | None |
Fusion | None |