HAMAP rule MF_01644
General rule information
[?]
| Accession |
MF_01644 |
| Dates |
14-JAN-2008 (Created)
1-JUN-2023 (Last updated, Version 19) |
| Scope |
Bacteria; Enterobacteriaceae |
Propagated annotation
[?]
Identifier, protein and gene names
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| Protein name |
|
RecName:
|
Full=D-phenylhydantoinase;
|
|
|
EC 3.5.2.-;
|
|
AltName:
|
Full=Hydantoin-utilizing enzyme HyuA;
|
|
| Function |
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown. |
| Catalytic activity |
RHEA:51664: D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine
|
| Cofactor |
a divalent metal cation
Note: Binds 2 divalent metal cations per subunit. |
| Subunit |
Homotetramer. |
| Ptm |
Carboxylation allows a single lysine to coordinate two divalent metal cations. |
| Similarity |
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. |
GO:0016812; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides.
| From: PHYDA_ECOLI (Q46806) |
|
Key
|
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From
|
|
To
|
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Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
|
BINDING
|
|
59
|
|
59
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
|
|
|
|
H
|
|
|
|
BINDING
|
|
61
|
|
61
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
|
|
|
|
H
|
|
|
|
BINDING
|
|
151
|
|
151
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" /note="via carbamate group
|
|
|
|
K
|
|
|
|
BINDING
|
|
151
|
|
151
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" /note="via carbamate group
|
|
|
|
K
|
|
|
|
BINDING
|
|
182
|
|
182
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2
|
|
|
|
H
|
|
|
|
BINDING
|
|
239
|
|
239
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2
|
|
|
|
H
|
|
|
|
BINDING
|
|
313
|
|
313
|
|
/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1
|
|
|
|
D
|
|
|
|
BINDING
|
|
156
|
|
156
|
|
/ligand="substrate
|
|
|
|
Y
|
|
|
|
BINDING
|
|
286
|
|
286
|
|
/ligand="substrate
|
|
|
|
S
|
|
|
|
BINDING
|
|
335
|
|
335
|
|
/ligand="substrate
|
|
|
|
N
|
|
|
|
MOD_RES
|
|
151
|
|
151
|
|
N6-carboxylysine
|
|
|
|
K
|
|
|
Additional information
[?]
| Size range |
461-461 amino acids |
| Related rules |
None |
| Fusion |
None |
