HAMAP rule MF_01649
General rule information
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Accession | MF_01649 |
Dates | 17-APR-2008 (Created)
20-JUL-2020 (Last updated, Version 17) |
Name | HcaF |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | Q47140 (HCAF_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01649 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HCAF |
Protein name | RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase subunit beta; EC=1.14.12.19; |
Gene name | Name=hcaF; |
Comments
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FUNCTION | Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. |
CATALYTIC ACTIVITY | Reaction=3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+); Xref=Rhea:RHEA:20357, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:51057, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.14.12.19; |
CATALYTIC ACTIVITY | Reaction=(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+); Xref=Rhea:RHEA:25058, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15669, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:61451; EC=1.14.12.19; |
PATHWAY | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
SUBUNIT | This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). |
SIMILARITY | Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family. |
Keywords
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Gene Ontology
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GO:0008695; Molecular function:3-phenylpropionate dioxygenase activity |
GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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Pfam | PF00866; Ring_hydroxyl_B; 1; |
Features
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Additional information
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Size range | 172-180 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |