HAMAP rule MF_01651

General rule information [?]

Accession	MF_01651
Dates	17-APR-2008 (Created) 19-NOV-2022 (Last updated, Version 18)

Name

HcaD

Scope

Bacteria; Enterobacterales

Template

P77650 (HCAD_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HCAD

Protein name

RecName:		Full=3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component;
		EC 1.18.1.3;

Gene name

hcaD

Comments [?]

Function	Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
Catalytic activity	RHEA:16521: H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin] EC 1.18.1.3
Cofactor	FAD
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit	This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD).
Similarity	Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.

Keywords [?]

Gene Ontology [?]

GO:0008695; Molecular function: 3-phenylpropionate dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Features [?]

From: HCAD_ECOLI (P77650)

Key From To Description Tag Condition FTGroup

BINDING 5 36 /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692

BINDING 146 174 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540

Additional information [?]