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| Annotation rule MF_01651 |
General rule information
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| Accession | MF_01651 |
| Dates | 17-APR-2008 (Created) 19-NOV-2019 (Last updated, Version 16) |
| Name | HcaD |
| Scope | Bacteria; Enterobacterales |
| Template | P77650 (HCAD_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. |
| Catalytic activity | RHEA:16521: H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]
EC 1.18.1.3 |
| Cofactor | FAD |
| Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| Subunit | This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). |
| Similarity | Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family. |
Keywords
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Gene Ontology
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GO:0008695; Molecular function: 3-phenylpropionate dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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Features
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| From: HCAD_ECOLI (P77650) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 5 | 36 | FAD | |||||||||
| NP_BIND | 146 | 174 | NAD | |||||||||
Additional information
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| Size range | 394-410 amino acids |
| Related rules | None |
| Fusion | None |