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HAMAP rule MF_01651

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General rule information [?]

Accession MF_01651
Dates 17-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 18)
Name HcaD
Scope(s) Bacteria
Template(s) P77650 (HCAD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01651 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HCAD
Protein name RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component;
Gene name Name=hcaD;

Comments [?]

FUNCTIONPart of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively.
CATALYTIC ACTIVITY Reaction=H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:16521, Rhea:RHEA- COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SUBUNITThis dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD).
SIMILARITYBelongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.

Keywords [?]

Gene Ontology [?]

GO:0008695; Molecular function:3-phenylpropionate dioxygenase activity
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

Pfam PF00070; Pyr_redox; 1;
Pfam PF07992; Pyr_redox_2; 1;

Features [?]

From: HCAD_ECOLI (P77650)
Key From To Description Tag Condition FTGroup
BINDING 5 36 /ligand="FAD"
BINDING 146 174 /ligand="NAD(+)"

Additional information [?]

Size range 394-410 amino acids
Related rules None
Fusion Nter: None Cter: None

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