HAMAP rule MF_01651
General rule information
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| Accession | MF_01651 |
| Dates | 17-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 18) |
| Name | HcaD |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P77650 (HCAD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01651 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HCAD |
| Protein name | RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component; EC=1.18.1.3; |
| Gene name | Name=hcaD; |
Comments
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| FUNCTION | Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. |
| CATALYTIC ACTIVITY | Reaction=H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:16521, Rhea:RHEA- COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.18.1.3; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| PATHWAY | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| SUBUNIT | This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). |
| SIMILARITY | Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family. |
Keywords
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Gene Ontology
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| GO:0008695; Molecular function:3-phenylpropionate dioxygenase activity |
| GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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Features
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| From: HCAD_ECOLI (P77650) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 5 | 36 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
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| BINDING | 146 | 174 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
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Additional information
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| Size range | 394-410 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |