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HAMAP rule MF_01665

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General rule information [?]

Accession MF_01665
Dates 8-JUL-2008 (Created)
19-NOV-2022 (Last updated, Version 17)
Name HemeA_synth_type2
Bacteria; Flavobacteriia
Bacteria; Alphaproteobacteria
Bacteria; Betaproteobacteria
Templates P12946 (CTAA_BACSU); Q3IXW9 (CTAA_CERS4): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Heme A synthase;
AltName: Full=Cytochrome aa3-controlling protein;
Gene name

Comments [?]

Function Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Catalytic activity RHEA:63388: 2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a
PhysiologicalDirection=left-to-right (RHEA:63389)
Cofactor heme b
Pathway Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
Subunit Interacts with CtaB.
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the COX15/CtaA family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0006784; Biological process: heme A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02628; COX15-CtaA; 1;

Computed features [?]

General Transmembrane; -; 8; trigger=yes;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     300     300       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     360     360       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  

Additional information [?]

Size range 325-391 amino acids
Related rules MF_01664 (CTAA)
Fusion None
Comments COX15/ctaA type 1 subfamily in MF_01664.