HAMAP rule MF_01665
General rule information
[?]
Accession | MF_01665 |
Dates | 8-JUL-2008 (Created) 19-NOV-2022 (Last updated, Version 17) |
Name | HemeA_synth_type2 |
Scope | Bacteria; Flavobacteriia
Bacteria; Alphaproteobacteria
Bacteria; Betaproteobacteria |
Templates | P12946 (CTAA_BACSU); Q3IXW9 (CTAA_CERS4): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A. |
Catalytic activity | RHEA:63388: 2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a
EC 1.17.99.9 PhysiologicalDirection=left-to-right (RHEA:63389) |
Cofactor | heme b |
Pathway | Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. |
Subunit | Interacts with CtaB. |
Subcellular location | Cell membrane; Multi-pass membrane protein. |
Similarity | Belongs to the COX15/CtaA family. Type 2 subfamily. |
Keywords
[?]
Cell membrane
Heme biosynthesis
Iron
Membrane
Metal-binding
Oxidoreductase
Transmembrane
Transmembrane helix
Heme biosynthesis
Iron
Membrane
Metal-binding
Oxidoreductase
Transmembrane
Transmembrane helix
Gene Ontology
[?]
GO:0006784; Biological process: heme A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Cross-references
[?]
Pfam | PF02628; COX15-CtaA; 1; |
Computed features
[?]
General | Transmembrane; -; 8; trigger=yes; |
Features
[?]
From: CTAA_CERS4 (Q3IXW9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 300 | 300 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue | H | ||||||||
BINDING | 360 | 360 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue | H |
Additional information
[?]
Size range | 325-391 amino acids |
Related rules | MF_01664 (CTAA) |
Fusion | None |
Comments | COX15/ctaA type 1 subfamily in MF_01664. |