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Annotation rule MF_01669 |
Accession | MF_01669 |
Dates | 29-SEP-2008 (Created) 19-NOV-2019 (Last updated, Version 11) |
Name | IolD |
Scope | Bacteria; Firmicutes |
Template | P42415 (IOLD_BACSU) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG). |
Catalytic activity | RHEA:25836: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)
EC 3.7.1.22 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
thiamine diphosphate Note: Binds 1 thiamine pyrophosphate per subunit. |
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Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7. |
Similarity | Belongs to the TPP enzyme family. |
PROSITE | PS00187; TPP_ENZYMES; 1; |
Pfam | PF02775; TPP_enzyme_C; 1; |
PF00205; TPP_enzyme_M; 1; | |
PF02776; TPP_enzyme_N; 1; |
From: IOLD_BACSU (P42415) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 442 | 522 | Thiamine pyrophosphate binding | |||||||||
METAL | 493 | 493 | Magnesium | D | ||||||||
METAL | 520 | 520 | Magnesium | N | ||||||||
BINDING | 66 | 66 | Thiamine pyrophosphate | E |
Size range | 637-645 amino acids |
Related rules | None |
Fusion | None |