HAMAP rule MF_01669

General rule information [?]

Accession	MF_01669
Dates	29-SEP-2008 (Created) 13-JAN-2023 (Last updated, Version 14)

Name

IolD

Scope

Bacteria; Bacillota

Template

P42415 (IOLD_BACSU)

Triggered by

HAMAP; MF_01669 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

IOLD

Protein name

RecName:		Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase;
		Short=THcHDO hydrolase;
		EC 3.7.1.22;

Gene name

iolD

Comments [?]

Function	Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).
Catalytic activity	RHEA:25836: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+) EC 3.7.1.22
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
	thiamine diphosphate Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7.
Similarity	Belongs to the TPP enzyme family.

Keywords [?]

Hydrolase
Magnesium
Metal-binding
NAD
Thiamine pyrophosphate

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016787; Molecular function: hydrolase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0019310; Biological process: inositol catabolic process.

Cross-references [?]

PROSITE	PS00187; TPP_ENZYMES; 1;
Pfam	PF02775; TPP_enzyme_C; 1;
	PF00205; TPP_enzyme_M; 1;
	PF02776; TPP_enzyme_N; 1;

Features [?]

From: IOLD_BACSU (P42415)

Key From To Description Tag Condition FTGroup

REGION 442 522 Thiamine pyrophosphate binding

BINDING 493 493 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 520 520 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N

BINDING 66 66 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 E

Additional information [?]

Size range	637-645 amino acids
Related rules	None
Fusion	None

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