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Annotation rule MF_01669
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General rule information [?]

Accession MF_01669
Dates 29-SEP-2008 (Created)
19-NOV-2019 (Last updated, Version 11)
Name IolD
Scope
Bacteria; Firmicutes
Template P42415 (IOLD_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IOLD
Protein name
RecName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase;
Short=THcHDO hydrolase;
EC 3.7.1.22;
Gene name
iolD

Comments [?]

Function Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).
Catalytic activity RHEA:25836: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)
EC 3.7.1.22
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
thiamine diphosphate
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7.
Similarity Belongs to the TPP enzyme family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016787; Molecular function: hydrolase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0019310; Biological process: inositol catabolic process.

Cross-references [?]

PROSITE PS00187; TPP_ENZYMES; 1;
Pfam PF02775; TPP_enzyme_C; 1;
PF00205; TPP_enzyme_M; 1;
PF02776; TPP_enzyme_N; 1;

Features [?]

From: IOLD_BACSU (P42415)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     442     522       Thiamine pyrophosphate binding        
METAL     493     493       Magnesium     D  
METAL     520     520       Magnesium     N  
BINDING     66     66       Thiamine pyrophosphate     E  

Additional information [?]

Size range 637-645 amino acids
Related rules None
Fusion None