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| Annotation rule MF_01669 |
General rule information
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| Accession | MF_01669 |
| Dates | 29-SEP-2008 (Created) 19-NOV-2019 (Last updated, Version 11) |
| Name | IolD |
| Scope | Bacteria; Firmicutes |
| Template | P42415 (IOLD_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG). |
| Catalytic activity | RHEA:25836: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)
EC 3.7.1.22 |
| Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
| thiamine diphosphate Note: Binds 1 thiamine pyrophosphate per subunit. |
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| Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7. |
| Similarity | Belongs to the TPP enzyme family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0016787; Molecular function: hydrolase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0019310; Biological process: inositol catabolic process.
GO:0016787; Molecular function: hydrolase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0019310; Biological process: inositol catabolic process.
Cross-references
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| PROSITE | PS00187; TPP_ENZYMES; 1; |
| Pfam | PF02775; TPP_enzyme_C; 1; |
| PF00205; TPP_enzyme_M; 1; | |
| PF02776; TPP_enzyme_N; 1; |
Features
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| From: IOLD_BACSU (P42415) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 442 | 522 | Thiamine pyrophosphate binding | |||||||||
| METAL | 493 | 493 | Magnesium | D | ||||||||
| METAL | 520 | 520 | Magnesium | N | ||||||||
| BINDING | 66 | 66 | Thiamine pyrophosphate | E | ||||||||
Additional information
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| Size range | 637-645 amino acids |
| Related rules | None |
| Fusion | None |