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HAMAP rule MF_01671

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General rule information [?]

Accession MF_01671
Dates 29-SEP-2008 (Created)
26-JAN-2023 (Last updated, Version 13)
Name IolG
Scope(s) Bacteria
Template(s) P26935 (IOLG_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01671 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IOLG
case <OC:Bacillota>
Protein name RecName: Full=Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
AltName: Full=Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
                 Short=MI 2-dehydrogenase/DCI 3-dehydrogenase;
Protein name RecName: Full=Inositol 2-dehydrogenase;
AltName: Full=Myo-inositol 2-dehydrogenase;
                 Short=MI 2-dehydrogenase;
end case
Gene name Name=iolG;

Comments [?]

case <OC:Bacillota>
FUNCTIONInvolved in the oxidation of myo-inositol (MI) and D-chiro- inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D- chiro-inositol (1KDCI), respectively.
FUNCTIONInvolved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose).
end case
CATALYTIC ACTIVITY Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose; Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268, ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
case <OC:Bacillota>
CATALYTIC ACTIVITY Reaction=1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine; Xref=Rhea:RHEA:25832, ChEBI:CHEBI:15378, ChEBI:CHEBI:27372, ChEBI:CHEBI:50920, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
PATHWAYPolyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7.
end case
SIMILARITYBelongs to the Gfo/Idh/MocA family.

Keywords [?]

Gene Ontology [?]

GO:0050112; Molecular function:inositol 2-dehydrogenase activity
GO:0019310; Biological process:inositol catabolic process

Cross-references [?]

Pfam PF01408; GFO_IDH_MocA; 1;
Pfam PF02894; GFO_IDH_MocA_C; 1;

Features [?]

Additional information [?]

Size range 329-366 amino acids
Related rules None
Fusion Nter: None Cter: None

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