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HAMAP rule MF_01671

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General rule information [?]

Accession MF_01671
Dates 29-SEP-2008 (Created)
26-JAN-2023 (Last updated, Version 13)
Name IolG
Scope
Bacteria; Actinomycetota
Bacteria; Bacillota
Bacteria; Pseudomonadota
Template P26935 (IOLG_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IOLG
case <OC:Bacillota>
Protein name
RecName: Full=Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
EC 1.1.1.18;
EC 1.1.1.369;
AltName: Full=Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
Short=MI 2-dehydrogenase/DCI 3-dehydrogenase;
else
Protein name
RecName: Full=Inositol 2-dehydrogenase;
EC 1.1.1.18;
AltName: Full=Myo-inositol 2-dehydrogenase;
Short=MI 2-dehydrogenase;
end case
Gene name
iolG

Comments [?]

case <OC:Bacillota>
Function Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.
else
Function Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
end case
Catalytic activity RHEA:16949: myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose
EC 1.1.1.18
case <OC:Bacillota>
Catalytic activity RHEA:25832: 1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine
EC 1.1.1.369
Pathway Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7.
end case
Subunit Homotetramer.
Similarity Belongs to the Gfo/Idh/MocA family.

Keywords [?]

NAD
Oxidoreductase

Gene Ontology [?]

GO:0050112; Molecular function: inositol 2-dehydrogenase activity.
GO:0019310; Biological process: inositol catabolic process.

Cross-references [?]

Pfam PF01408; GFO_IDH_MocA; 1;
PF02894; GFO_IDH_MocA_C; 1;

Additional information [?]

Size range 329-366 amino acids
Related rules None
Fusion None


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