HAMAP rule MF_01671

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01671
Accession	MF_01671
Dates	29-SEP-2008 (Created) 03-SEP-2024 (Last updated, Version 16)
Name	IolG
Scope(s)	Bacteria Actinomycetota Bacillota Pseudomonadota
Template(s)	P26935; [ Recover all ]
Triggered by	HAMAP; MF_01671 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	IOLG
case <OC:Bacillota>
Protein name	RecName: Full=Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; EC=1.1.1.18; EC=1.1.1.369; AltName: Full=Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Short=MI 2-dehydrogenase/DCI 3-dehydrogenase;
else
Protein name	RecName: Full=Inositol 2-dehydrogenase; EC=1.1.1.18; AltName: Full=Myo-inositol 2-dehydrogenase; Short=MI 2-dehydrogenase;
end case
Gene name	Name=iolG;

Comments [?]

case <OC:Bacillota>
FUNCTION	Involved in the oxidation of myo-inositol (MI) and D-chiro- inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D- chiro-inositol (1KDCI), respectively.
else
FUNCTION	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose).
end case
CATALYTIC ACTIVITY	Reaction=myo-inositol + NAD(+) = scyllo-inosose + NADH + H(+); Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268, ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
case <OC:Bacillota>
CATALYTIC ACTIVITY	Reaction=1D-chiro-inositol + NAD(+) = scyllo-inosine + NADH + H(+); Xref=Rhea:RHEA:25832, ChEBI:CHEBI:15378, ChEBI:CHEBI:27372, ChEBI:CHEBI:50920, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.369;
PATHWAY	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7.
end case
SUBUNIT	Homotetramer.
SIMILARITY	Belongs to the Gfo/Idh/MocA family.

Keywords [?]

Gene Ontology [?]

GO:0050112; Molecular function:inositol 2-dehydrogenase (NAD+) activity

GO:0019310; Biological process:inositol catabolic process

Cross-references [?]

Pfam	PF01408; GFO_IDH_MocA; 1;
Pfam	PF02894; GFO_IDH_MocA_C; 1;

Features [?]

Additional information [?]