HAMAP rule MF_01672

General rule information [?]

Accession	MF_01672
Dates	29-SEP-2008 (Created) 17-FEB-2023 (Last updated, Version 13)
Name	IolE
Scope(s)	Bacteria Bacillota Gammaproteobacteria Mycoplasmatota
Template(s)	P42416 (IOLE_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_01672 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	IOLE
Protein name	RecName: Full=Inosose dehydratase; EC=4.2.1.44; AltName: Full=2-keto-myo-inositol dehydratase; Short=2KMI dehydratase;
Gene name	Name=iolE;

Comments [?]

FUNCTION	Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
CATALYTIC ACTIVITY	Reaction=scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O; Xref=Rhea:RHEA:14065, ChEBI:CHEBI:15377, ChEBI:CHEBI:17811, ChEBI:CHEBI:28446; EC=4.2.1.44;
COFACTOR	Name=glutathione; Xref=ChEBI:CHEBI:57925;
COFACTOR	Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
case <OC:Bacillota>
PATHWAY	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.
end case
SIMILARITY	Belongs to the IolE/MocC family.

Keywords [?]

Gene Ontology [?]

GO:0030145; Molecular function:manganese ion binding

GO:0050114; Molecular function:myo-inosose-2 dehydratase activity

GO:0019310; Biological process:inositol catabolic process

Cross-references [?]

Pfam	PF01261; AP_endonuc_2; 1;

Features [?]

Additional information [?]