HAMAP rule MF_01672
General rule information
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Accession | MF_01672 |
Dates | 29-SEP-2008 (Created)
17-FEB-2023 (Last updated, Version 13) |
Name | IolE |
Scope(s) |
Bacteria Bacillota Gammaproteobacteria Mycoplasmatota |
Template(s) | P42416 (IOLE_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01672 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | IOLE |
Protein name | RecName: Full=Inosose dehydratase; EC=4.2.1.44; AltName: Full=2-keto-myo-inositol dehydratase; Short=2KMI dehydratase; |
Gene name | Name=iolE; |
Comments
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FUNCTION | Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). |
CATALYTIC ACTIVITY | Reaction=scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O; Xref=Rhea:RHEA:14065, ChEBI:CHEBI:15377, ChEBI:CHEBI:17811, ChEBI:CHEBI:28446; EC=4.2.1.44; |
COFACTOR | Name=glutathione; Xref=ChEBI:CHEBI:57925; |
COFACTOR | Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
case <OC:Bacillota> | |
PATHWAY | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7. |
end case | |
SIMILARITY | Belongs to the IolE/MocC family. |
Keywords
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Gene Ontology
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GO:0030145; Molecular function:manganese ion binding |
GO:0050114; Molecular function:myo-inosose-2 dehydratase activity |
GO:0019310; Biological process:inositol catabolic process |
Cross-references
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Pfam | PF01261; AP_endonuc_2; 1; |
Features
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Additional information
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Size range | 297-308 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |