HAMAP rule MF_01672
General rule information
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| Accession | MF_01672 |
| Dates | 29-SEP-2008 (Created) 17-FEB-2023 (Last updated, Version 13) |
| Name | IolE |
| Scope | Bacteria; Bacillota
Bacteria; Gammaproteobacteria
Bacteria; Mycoplasmatota |
| Template | P42416 (IOLE_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). |
| Catalytic activity | RHEA:14065: scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O
EC 4.2.1.44 |
| Cofactor | glutathione |
| Co(2+) Mn(2+) |
case <OC:Bacillota>
| Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7. |
end case
| Similarity | Belongs to the IolE/MocC family. |
Keywords
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Gene Ontology
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GO:0030145; Molecular function: manganese ion binding.
GO:0050114; Molecular function: myo-inosose-2 dehydratase activity.
GO:0019310; Biological process: inositol catabolic process.
GO:0050114; Molecular function: myo-inosose-2 dehydratase activity.
GO:0019310; Biological process: inositol catabolic process.
Cross-references
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| Pfam | PF01261; AP_endonuc_2; 1; |
Additional information
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| Size range | 297-308 amino acids |
| Related rules | None |
| Fusion | None |