HAMAP rule MF_01681

Accession	MF_01681
Dates	24-OCT-2008 (Created) 1-JUN-2023 (Last updated, Version 16)

Name	Salvage_MtnC

Scope

Bacteria

Template

P0C8L5 (MTNC_KLEAE)

Triggered by

HAMAP; MF_01681 (Get profile general information and statistics)

Identifier

MTNC

Protein name

RecName: Full=Enolase-phosphatase E1; EC 3.1.3.77; AltName: Full=2,3-diketo-5-methylthio-1-phosphopentane phosphatase;

Gene name

mtnC

Function	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Catalytic activity	RHEA:21700: 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate EC 3.1.3.77
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.
	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.
Subunit	Monomer.
Similarity	Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.

Amino-acid biosynthesis
Hydrolase
Magnesium
Metal-binding
Methionine biosynthesis

GO:0000287; Molecular function: magnesium ion binding.
GO:0043715; Molecular function: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity.
GO:0043716; Molecular function: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.

Pfam	PF00702; Hydrolase; 1;
PRINTS	PR00413; HADHALOGNASE; 1;
NCBIfam	TIGR01691; Enolase-ppase; 1;
	TIGR01549; HAD-SF-IA-v1; 1;
	TIGR01509; HAD-SF-IA-v3; 1;

Size range	221-253 amino acids
Related rules	None
Fusion	None

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