HAMAP rule MF_01684
General rule information
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Accession | MF_01684 |
Dates | 19-NOV-2008 (Created) 14-MAY-2022 (Last updated, Version 22) |
Name | Salvage_MtnN |
Scope | Bacteria |
Templates | P0AF12 (MTNN_ECOLI); O32028 (MTNN_BACSU); Q9R4A1 (MTNN_KLEPN): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Enterobacterales>
Function | Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. |
else
Function | Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. |
end case
Catalytic activity | RHEA:17805: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
EC 3.2.2.9 |
RHEA:13617: H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine
EC 3.2.2.9 |
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RHEA:29859: 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
EC 3.2.2.9 PhysiologicalDirection=left-to-right (RHEA:29860) |
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Pathway | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. |
case <OC:Enterobacterales>
Subunit | Homodimer. |
end case
Similarity | Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. |
Keywords
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Gene Ontology
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GO:0008782; Molecular function: adenosylhomocysteine nucleosidase activity.
GO:0008930; Molecular function: methylthioadenosine nucleosidase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.
GO:0008930; Molecular function: methylthioadenosine nucleosidase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.
case <OC:Enterobacterales>
GO:0046124; Biological process: purine deoxyribonucleoside catabolic process.
end case
Cross-references
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Features
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From: MTNN_ECOLI (P0AF12) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 173 | 174 | /ligand="substrate | M-[ED] | ||||||||
ACT_SITE | 12 | 12 | Proton acceptor | E | ||||||||
ACT_SITE | 197 | 197 | Proton donor | D | ||||||||
BINDING | 78 | 78 | /ligand="substrate | [GA] | ||||||||
BINDING | 152 | 152 | /ligand="substrate | [IVML] |
Additional information
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Size range | 221-251 amino acids |
Related rules | None |
Fusion | None |