HAMAP rule MF_01691

General rule information [?]

Accession	MF_01691
Dates	30-APR-2009 (Created) 13-JAN-2023 (Last updated, Version 11)

Name

DapH

Scope

Bacteria; Bacillota

Bacteria; Thermotogae

Archaea

Template

O34981 (DAPH_BACSU)

Triggered by

HAMAP; MF_01691 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DAPH

Protein name

RecName:		Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase;
		EC 2.3.1.89;
AltName:		Full=Tetrahydrodipicolinate N-acetyltransferase;
		Short=THP acetyltransferase;
		Short=Tetrahydropicolinate acetylase;

Gene name

dapH

Comments [?]

Function	Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
Catalytic activity	RHEA:13085: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate EC 2.3.1.89
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3.
Similarity	Belongs to the transferase hexapeptide repeat family. DapH subfamily.

Keywords [?]

Acyltransferase
Amino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
Repeat
Transferase

Gene Ontology [?]

GO:0016407; Molecular function: acetyltransferase activity.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.

Cross-references [?]

PROSITE	PS00101; HEXAPEP_TRANSFERASES; 1;
Pfam	PF08503; DapH_N; 1;
	PF00132; Hexapep; 4;

Additional information [?]

Size range	228-257 amino acids
Related rules	None
Fusion	None

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