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Annotation rule MF_01695
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General rule information [?]

Accession MF_01695
Dates 20-SEP-2010 (Created)
19-NOV-2019 (Last updated, Version 8)
Name MshA
Scope
Bacteria; Actinobacteria
Templates Q8NTA6 (MSHA_CORGL); P9WMY7 (MSHA_MYCTU); A0QQZ8 (MSHA_MYCS2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSHA
Protein name
RecName: Full=D-inositol-3-phosphate glycosyltransferase;
EC 2.4.1.250;
AltName: Full=N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase;
Short=GlcNAc-Ins-P N-acetylglucosaminyltransferase;
Gene name
mshA

Comments [?]

Function Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
Catalytic activity RHEA:26188: 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP
EC 2.4.1.250
Subunit Homodimer.
Similarity Belongs to the glycosyltransferase group 1 family. MshA subfamily.

Keywords [?]

Glycosyltransferase
Magnesium
Metal-binding
Transferase

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0008375; Molecular function: acetylglucosaminyltransferase activity.
GO:0010125; Biological process: mycothiol biosynthetic process.

Cross-references [?]

Pfam PF08323; Glyco_transf_5; 1;
PF00534; Glycos_transf_1; 1;
TIGRFAMs TIGR03449; Mycothiol_MshA; 1;

Features [?]

From: MSHA_CORGL (Q8NTA6)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     15     16       UDP-GlcNAc binding     Q-P  
REGION     20     25       1D-inositol 3-phosphate binding     D-x-G-x-[ML]-N  
METAL     303     303       Magnesium; via carbonyl oxygen     [YFIM]  
METAL     304     304       Magnesium; via carbonyl oxygen     [RHQ]  
METAL     306     306       Magnesium; via carbonyl oxygen     [ACSV]  
METAL     330     330       Magnesium     T  
BINDING     9     9       1D-inositol 3-phosphate     H  
BINDING     23     23       UDP-GlcNAc; via amide nitrogen     G  
BINDING     78     78       1D-inositol 3-phosphate     [KR]  
BINDING     110     110       1D-inositol 3-phosphate     [YH]  
BINDING     134     134       1D-inositol 3-phosphate     [TS]  
BINDING     154     154       1D-inositol 3-phosphate     [RQ]  
BINDING     231     231       UDP-GlcNAc     R  
BINDING     236     236       UDP-GlcNAc     K  
BINDING     294     294       UDP-GlcNAc; via amide nitrogen and carbonyl oxygen     [RMQV]  
BINDING     316     316       UDP-GlcNAc     E  
BINDING     324     324       UDP-GlcNAc     E  

Additional information [?]

Size range 407-496 amino acids
Related rules None
Fusion None


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