HAMAP rule MF_01698

General rule information [?]

Accession	MF_01698
Dates	20-SEP-2010 (Created) 1-JUN-2023 (Last updated, Version 13)

Name

MshD

Scope

Bacteria; Actinomycetota

Templates

P9WJM7 (MSHD_MYCTU); A4ZHT6 (MSHD_MYCS2): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MSHD

Protein name

RecName:		Full=Mycothiol acetyltransferase;
		Short=MSH acetyltransferase;
		EC 2.3.1.189;
AltName:		Full=Mycothiol synthase;

Gene name

mshD

Comments [?]

Function	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
Catalytic activity	RHEA:26172: 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol EC 2.3.1.189
Subunit	Monomer.
Similarity	Belongs to the acetyltransferase family. MshD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0035447; Molecular function: mycothiol synthase activity.
GO:0010125; Biological process: mycothiol biosynthetic process.

Cross-references [?]

Features [?]

From: MSHD_MYCTU (P9WJM7)

Key From To Description Tag Condition FTGroup

BINDING 80 82 /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" /ligand_label="1 [LAIV]-x-[VADIT]

BINDING 88 93 /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" /ligand_label="1 [RHK]-[RQEHILN]-[GA]-x-[GAV]-[TS]

BINDING 238 240 /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" /ligand_label="2 [LIV]-x-[VILT]

BINDING 245 251 /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" /ligand_label="2 x-[RACGI]-x-G-x-[AG]-[DHKQRSTY]

BINDING 287 292 /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" /ligand_label="2 N-x(4)-[RHKNQ]

BINDING 36 36 /ligand="1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside" /ligand_id="ChEBI:CHEBI:58887 [ED]

BINDING 179 179 /ligand="1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside" /ligand_id="ChEBI:CHEBI:58887 [ED]

BINDING 224 224 /ligand="1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside" /ligand_id="ChEBI:CHEBI:58887 [KR]

BINDING 234 234 /ligand="1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside" /ligand_id="ChEBI:CHEBI:58887 E

BINDING 282 282 /ligand="1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside" /ligand_id="ChEBI:CHEBI:58887 Y

Additional information [?]