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Annotation rule MF_01698
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General rule information [?]

Accession MF_01698
Dates 20-SEP-2010 (Created)
19-NOV-2019 (Last updated, Version 8)
Name MshD
Scope
Bacteria; Actinobacteria
Templates P9WJM7 (MSHD_MYCTU); A4ZHT6 (MSHD_MYCS2): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSHD
Protein name
RecName: Full=Mycothiol acetyltransferase;
Short=MSH acetyltransferase;
EC 2.3.1.189;
AltName: Full=Mycothiol synthase;
Gene name
mshD

Comments [?]

Function Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
Catalytic activity RHEA:26172: 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol
EC 2.3.1.189
Subunit Monomer.
Similarity Belongs to the acetyltransferase family. MshD subfamily.

Keywords [?]


Gene Ontology [?]

GO:0035447; Molecular function: mycothiol synthase activity.
GO:0010125; Biological process: mycothiol biosynthetic process.

Cross-references [?]

PROSITE PS51186; GNAT; 2; trigger=PRU00532;
Pfam PF00583; Acetyltransf_1; 1;
TIGRFAMs TIGR03448; Mycothiol_MshD; 1;

Features [?]

From: MSHD_MYCTU (P9WJM7)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     80     82       Acetyl-CoA binding 1     [LAIV]-x-[VADIT]  
REGION     88     93       Acetyl-CoA binding 1     [RHK]-[RQEHILN]-[GA]-x-[GAV]-[TS]  
REGION     238     240       Acetyl-CoA binding 2     [LIV]-x-[VILT]  
REGION     245     251       Acetyl-CoA binding 2     x-[RACGI]-x-G-x-[AG]-[DHKQRSTY]  
REGION     287     292       Acetyl-CoA binding 2     N-x(4)-[RHKNQ]  
BINDING     36     36       Desacetylmycothiol; via amide nitrogen     [ED]  
BINDING     179     179       Desacetylmycothiol     [ED]  
BINDING     224     224       Desacetylmycothiol     [KR]  
BINDING     234     234       Desacetylmycothiol     E  
BINDING     282     282       Desacetylmycothiol; via carbonyl oxygen     Y  

Additional information [?]

Size range 174-367 amino acids
Related rules None
Fusion None