HAMAP rule MF_01698

General rule information [?]

Accession	MF_01698
Dates	20-SEP-2010 (Created) 1-JUN-2023 (Last updated, Version 13)
Name	MshD
Scope(s)	Bacteria Actinomycetota
Template(s)	P9WJM7 (MSHD_MYCTU); A4ZHT6 (MSHD_MYCS2); [ Recover all ]
Triggered by	HAMAP; MF_01698 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MSHD
Protein name	RecName: Full=Mycothiol acetyltransferase; Short=MSH acetyltransferase; EC=2.3.1.189; AltName: Full=Mycothiol synthase;
Gene name	Name=mshD;

Comments [?]

FUNCTION	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
CATALYTIC ACTIVITY	Reaction=1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D- glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol; Xref=Rhea:RHEA:26172, ChEBI:CHEBI:15378, ChEBI:CHEBI:16768, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58887; EC=2.3.1.189;
SUBUNIT	Monomer.
SIMILARITY	Belongs to the acetyltransferase family. MshD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0035447; Molecular function:mycothiol synthase activity

GO:0010125; Biological process:mycothiol biosynthetic process

Cross-references [?]

Features [?]

From: MSHD_MYCTU (P9WJM7)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"
/ligand_label="1"

[LAIV]-x-[VADIT]

BINDING

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"
/ligand_label="1"

[RHK]-[RQEHILN]-[GA]-x-[GAV]-[TS]

BINDING

238

240

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"
/ligand_label="2"

[LIV]-x-[VILT]

BINDING

245

251

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"
/ligand_label="2"

x-[RACGI]-x-G-x-[AG]-[DHKQRSTY]

BINDING

287

292

/ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"
/ligand_label="2"

N-x(4)-[RHKNQ]

BINDING