HAMAP logo

HAMAP rule MF_01808

Send feedback

General rule information [?]

Accession MF_01808
Dates 17-AUG-2003 (Created)
1-JUN-2023 (Last updated, Version 37)
Name Recomb_XerC_XerD
Scope(s) Bacteria
Template(s) P0A8P6 (XERC_ECOLI); P44818 (XERC_HAEIN); Q51566 (XERC_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_01808 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier XERC
Protein name RecName: Full=Tyrosine recombinase XerC;
Gene name Name=xerC;

Comments [?]

case <OC:Enterobacterales>
FUNCTIONSite-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.
ACTIVITY REGULATIONFtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
SUBUNITForms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
else
FUNCTIONSite-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
SUBUNITForms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the 'phage' integrase family. XerC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0009037; Molecular function:tyrosine-based site-specific recombinase activity
GO:0007059; Biological process:chromosome segregation
GO:0006310; Biological process:DNA recombination
GO:0006313; Biological process:DNA transposition
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00589; Phage_integrase; 1;
Pfam PF02899; Phage_integr_N; 1;
NCBIfam TIGR02224; Recomb_XerC; 1;
PROSITE PS51900; CB; 1;
PROSITE PS51898; TYR_RECOMBINASE; 1;

Features [?]

From: XERC_ECOLI (P0A8P6)
Key From To Description Tag Condition FTGroup
ACT_SITE 148 148 R
ACT_SITE 172 172 K
ACT_SITE 240 240 H
ACT_SITE 243 243 R
ACT_SITE 266 266 H
ACT_SITE 275 275 /note="O-(3'-phospho-DNA)-tyrosine intermediate" Y

Additional information [?]

Size range 250-356 amino acids
Related rules MF_01807
Fusion Nter: None Cter: None
Comments XerC is highly related to XerD and it is therefore difficult to discriminate them correctly. Most XerD proteins however contain a [ST]RQ tripeptide that allow to distinguish them from XerC. Entries that are matched by MF_01808 profile but not by MF_01807 are annotated as XerC. Entries that are matched by MF_01808 and MF_01807 profiles are annotated as XerD.



View rule in raw text format (no links)