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Annotation rule MF_01808
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General rule information [?]

Accession MF_01808
Dates 17-AUG-2003 (Created)
19-NOV-2019 (Last updated, Version 35)
Name Recomb_XerC_XerD
Scope
Bacteria
Templates P0A8P6 (XERC_ECOLI); P44818 (XERC_HAEIN); Q51566 (XERC_PSEAE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XERC
Protein name
RecName: Full=Tyrosine recombinase XerC;
Gene name
xerC

Comments [?]

case <OC:Enterobacterales>
Function Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.
Activity regulation FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
Subunit Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
else
Function Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
Subunit Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the 'phage' integrase family. XerC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006313; Biological process: transposition, DNA-mediated.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00589; Phage_integrase; 1;
PF02899; Phage_integr_N; 1;
TIGRFAMs TIGR02224; Recomb_XerC; 1;
PROSITE PS51900; CB; 1; trigger=PRU01248;
PS51898; TYR_RECOMBINASE; 1; trigger=PRU01246;

Features [?]

From: XERC_ECOLI (P0A8P6)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     148     148             R  
ACT_SITE     172     172             K  
ACT_SITE     240     240             H  
ACT_SITE     243     243             R  
ACT_SITE     266     266             H  
ACT_SITE     275     275       O-(3'-phospho-DNA)-tyrosine intermediate     Y  

Additional information [?]

Size range 250-356 amino acids
Related rules MF_01807 (XERD supersedes the current rule)
Fusion None
Comments XerC is highly related to XerD and it is therefore difficult to discriminate them correctly. Most XerD proteins however contain a [ST]RQ tripeptide that allow to distinguish them from XerC. Entries that are matched by MF_01808 profile but not by MF_01807 are annotated as XerC. Entries that are matched by MF_01808 and MF_01807 profiles are annotated as XerD.