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HAMAP rule MF_01810

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General rule information [?]

Accession MF_01810
Dates 17-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 30)
Name YidC_type1
Scope(s) Bacteria
Template(s) P25714 (YIDC_ECOLI); P74155 (YIDC_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_01810 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier YIDC
Protein name RecName: Full=Membrane protein insertase YidC;
AltName: Full=Foldase YidC;
AltName: Full=Membrane protein YidC;
AltName: Full=Membrane integrase YidC;
Gene name Name=yidC;

Comments [?]

FUNCTIONRequired for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
FUNCTIONProbably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.
end case
SUBUNITInteracts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Keywords [?]

Protein transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02096; 60KD_IMP; 1;
NCBIfam TIGR03593; YidC_nterm; 1;
NCBIfam TIGR03592; YidC_oxa1_C; 1;
General Transmembrane; -; 4-8;

Features [?]

Additional information [?]

Size range 310-795 amino acids
Related rules MF_01811
Fusion Nter: <PDZ/DHR> Cter: None
Comments N-terminal PDZ/DHR fused in RHOBA. TIGR03593 describes a large N- terminal domain of unknown function not found in all members. In most Bacillota (MF_01811), this protein is much shorter and is probably a lipoprotein. Chlamydiota have been annotated as lipoproteins. Streptomyces seem to only have 3 transmembrane helices.

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