HAMAP rule MF_01810
General rule information
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| Accession | MF_01810 |
| Dates | 17-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | YidC_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P25714 (YIDC_ECOLI); P74155 (YIDC_SYNY3); [ Recover all ] |
| Triggered by |
HAMAP; MF_01810 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YIDC |
| Protein name | RecName: Full=Membrane protein insertase YidC; AltName: Full=Foldase YidC; AltName: Full=Membrane protein YidC; AltName: Full=Membrane integrase YidC; |
| Gene name | Name=yidC; |
Comments
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| FUNCTION | Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. |
| case <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| FUNCTION | Probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid. |
| end case | |
| SUBUNIT | Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily. |
Keywords
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| Chaperone | |
| Membrane | |
| Protein transport | |
| Transmembrane | |
| Transport | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Transmembrane helix | |
Gene Ontology
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| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF02096; 60KD_IMP; 1; |
| PRINTS | PR00701; 60KDINNERMP; 1; |
| NCBIfam | TIGR03593; YidC_nterm; 1; |
| NCBIfam | TIGR03592; YidC_oxa1_C; 1; |
| General | Transmembrane; -; 4-8; |
Features
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Additional information
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| Size range | 310-795 amino acids |
| Related rules |
MF_01811 |
| Fusion | Nter: <PDZ/DHR> Cter: None |
| Comments | N-terminal PDZ/DHR fused in RHOBA. TIGR03593 describes a large N- terminal domain of unknown function not found in all members. In most Bacillota (MF_01811), this protein is much shorter and is probably a lipoprotein. Chlamydiota have been annotated as lipoproteins. Streptomyces seem to only have 3 transmembrane helices. |