HAMAP rule MF_01811

General rule information [?]

Accession	MF_01811
Dates	17-NOV-2003 (Created) 17-JAN-2023 (Last updated, Version 26)

Name	YidC_type2

Scope

Bacteria; Bacillota

Templates

Q01625 (MISCA_BACSU); P54544 (MISCB_BACSU); Q8DVX3 (YIDC1_STRMU); Q8DSP8 (YIDC2_STRMU): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

YIDC

Protein name

RecName:		Full=Membrane protein insertase YidC;
AltName:		Full=Foldase YidC;
AltName:		Full=Membrane protein YidC;
AltName:		Full=Membrane integrase YidC;
Flags:		Precursor;

Gene name

yidC

Comments [?]

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Similarity	Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.

Keywords [?]

case <Feature:PS51257>

end case

Gene Ontology [?]

GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF02096; 60KD_IMP; 1;
PRINTS	PR00701; 60KDINNERMP; 1;
TIGRFAMs	TIGR03592; YidC_oxa1_C; 1;
PROSITE	PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;

Computed features [?]

General

Transmembrane; -; 4-6; trigger=yes;

Additional information [?]

Size range	252-320 amino acids
Related rules	MF_01810 (YIDC)
Fusion	None
Comments	This family, which is specific to most Bacillota, is closely related to the protein family (MF_01810) and displays a similar function. These proteins, which are often present in two copies, are however much shorter than MF_01810 proteins, and are probably lipoproteins. In the 2 organisms in which they have been studied they have overlapping but not identical functions.