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HAMAP rule MF_01812

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General rule information [?]

Accession MF_01812
Dates 30-JUN-2003 (Created)
19-NOV-2022 (Last updated, Version 28)
Name Eis
Scope(s) Bacteria
Template(s) P9WFK7 (EIS_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_01812 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Mycobacterium tuberculosis complex>
Identifier EIS
Protein name RecName: Full=N-acetyltransferase Eis;
AltName: Full=Enhanced intracellular survival protein;
AltName: Full=Protein-lysine N-acetyltransferase;
Gene name Name=eis;
else case <OC:Mycobacterium> and not <OC:Mycobacterium tuberculosis complex>
Identifier EIS
Protein name RecName: Full=N-acetyltransferase Eis;
Gene name Name=eis;
Identifier Ynnn
Protein name RecName: Full=Uncharacterized N-acetyltransferase ;
end case

Comments [?]

case <OC:Mycobacterium tuberculosis complex>
FUNCTIONEffector that is released into the host cell and affects host immune responses. Acts as an acetyltransferase that acetylates lysine residues of host proteins.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930;
SUBCELLULAR LOCATIONSecreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, Bacterial extracellular vesicle. Host extracellular space.
end case
SUBUNITHomohexamer; trimer of dimers.
SIMILARITYBelongs to the acetyltransferase Eis family.

Keywords [?]

case <OC:Mycobacterium tuberculosis complex>
Host cytoplasmic vesicle
end case

Gene Ontology [?]

GO:0008080; Molecular function:N-acetyltransferase activity

Cross-references [?]

Pfam PF13530; SCP2_2; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 85 87 /ligand="acetyl-CoA"
BINDING 93 98 /ligand="acetyl-CoA"
BINDING 121 122 /ligand="acetyl-CoA"
ACT_SITE 126 126 /note="Proton donor" Y
ACT_SITE Cter Cter /note="Proton acceptor; via carboxylate" [FY]

Additional information [?]

Size range 408-418 amino acids
Related rules None
Fusion Nter: None Cter: None

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