HAMAP logo

HAMAP rule MF_01812

Send feedback

General rule information [?]

Accession MF_01812
Dates 30-JUN-2003 (Created)
19-NOV-2022 (Last updated, Version 28)
Name Eis
Scope
Bacteria
Template P9WFK7 (EIS_MYCTU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Mycobacterium tuberculosis complex>
Identifier
EIS
Protein name
RecName: Full=N-acetyltransferase Eis;
EC 2.3.1.-;
AltName: Full=Enhanced intracellular survival protein;
AltName: Full=Protein-lysine N-acetyltransferase;
Gene name
eis
else case <OC:Mycobacterium> and not <OC:Mycobacterium tuberculosis complex>
Identifier
EIS
Protein name
RecName: Full=N-acetyltransferase Eis;
EC 2.3.1.-;
Gene name
eis
else
Identifier
Ynnn
Protein name
RecName: Full=Uncharacterized N-acetyltransferase ;
EC 2.3.1.-;
end case

Comments [?]

case <OC:Mycobacterium tuberculosis complex>
Function Effector that is released into the host cell and affects host immune responses. Acts as an acetyltransferase that acetylates lysine residues of host proteins.
Catalytic activity RHEA:45948: acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
Subcellular location Secreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, Bacterial extracellular vesicle. Host extracellular space.
end case
Subunit Homohexamer; trimer of dimers.
Similarity Belongs to the acetyltransferase Eis family.

Keywords [?]

Acyltransferase
Transferase
case <OC:Mycobacterium tuberculosis complex>
Host cytoplasmic vesicle
Secreted
end case

Gene Ontology [?]

GO:0008080; Molecular function: N-acetyltransferase activity.

Cross-references [?]

PROSITE PS51186; GNAT; 1; trigger=PRU00532;
Pfam PF13530; SCP2_2; 1;

Features [?]

From: EIS_MYCTU (P9WFK7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     85     87       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     [VIA]-x-V  
BINDING     93     98       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288        
BINDING (Optional)     121     122       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     [ST]-E  
ACT_SITE     126     126       Proton donor     Y  
ACT_SITE     Cter     Cter       Proton acceptor; via carboxylate     [FY]  

Additional information [?]

Size range 408-418 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)