HAMAP rule MF_01812
General rule information
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Accession |
MF_01812 |
Dates |
30-JUN-2003 (Created) 19-NOV-2022 (Last updated, Version 28) |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Mycobacterium tuberculosis complex>
Protein name |
RecName:
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Full=N-acetyltransferase Eis;
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EC 2.3.1.-;
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AltName:
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Full=Enhanced intracellular survival protein;
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AltName:
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Full=Protein-lysine N-acetyltransferase;
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else case <OC:Mycobacterium> and not <OC:Mycobacterium tuberculosis complex>
Protein name |
RecName:
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Full=N-acetyltransferase Eis;
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EC 2.3.1.-;
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else
Protein name |
RecName:
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Full=Uncharacterized N-acetyltransferase ;
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EC 2.3.1.-;
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end case
case <OC:Mycobacterium tuberculosis complex>
Function |
Effector that is released into the host cell and affects host immune responses. Acts as an acetyltransferase that acetylates lysine residues of host proteins. |
Catalytic activity |
RHEA:45948: acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
|
Subcellular location |
Secreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, Bacterial extracellular vesicle. Host extracellular space. |
end case
Subunit |
Homohexamer; trimer of dimers. |
Similarity |
Belongs to the acetyltransferase Eis family. |
case <OC:Mycobacterium tuberculosis complex>
end case
GO:0008080; Molecular function: N-acetyltransferase activity.
From: EIS_MYCTU (P9WFK7) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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85
|
|
87
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/ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288
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[VIA]-x-V
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BINDING
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93
|
|
98
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/ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288
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|
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BINDING (Optional)
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121
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122
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/ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288
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[ST]-E
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ACT_SITE
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126
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126
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Proton donor
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Y
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ACT_SITE
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Cter
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Cter
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Proton acceptor; via carboxylate
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[FY]
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Additional information
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Size range |
408-418 amino acids |
Related rules |
None |
Fusion |
None |