HAMAP rule MF_01812
General rule information
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| Accession | MF_01812 |
| Dates | 30-JUN-2003 (Created)
19-NOV-2022 (Last updated, Version 28) |
| Name | Eis |
| Scope(s) |
Bacteria |
| Template(s) | P9WFK7 (EIS_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01812 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Mycobacterium tuberculosis complex> | |
| Identifier | EIS |
| Protein name | RecName: Full=N-acetyltransferase Eis; EC=2.3.1.-; AltName: Full=Enhanced intracellular survival protein; AltName: Full=Protein-lysine N-acetyltransferase; |
| Gene name | Name=eis; |
| else case <OC:Mycobacterium> and not <OC:Mycobacterium tuberculosis complex> | |
| Identifier | EIS |
| Protein name | RecName: Full=N-acetyltransferase Eis; EC=2.3.1.-; |
| Gene name | Name=eis; |
| else | |
| Identifier | Ynnn |
| Protein name | RecName: Full=Uncharacterized N-acetyltransferase EC=2.3.1.-; |
| end case | |
Comments
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| case <OC:Mycobacterium tuberculosis complex> | |
| FUNCTION | Effector that is released into the host cell and affects host immune responses. Acts as an acetyltransferase that acetylates lysine residues of host proteins. |
| CATALYTIC ACTIVITY | Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; |
| SUBCELLULAR LOCATION | Secreted. Host cytoplasmic vesicle, host phagosome. Extracellular vesicle, Bacterial extracellular vesicle. Host extracellular space. |
| end case | |
| SUBUNIT | Homohexamer; trimer of dimers. |
| SIMILARITY | Belongs to the acetyltransferase Eis family. |
Keywords
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| Acyltransferase | |
| Transferase | |
| case <OC:Mycobacterium tuberculosis complex> | |
| Host cytoplasmic vesicle | |
| Secreted | |
| end case | |
Gene Ontology
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| GO:0008080; Molecular function:N-acetyltransferase activity |
Cross-references
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Features
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| From: EIS_MYCTU (P9WFK7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 85 | 87 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
[VIA]-x-V | ||||||||
| BINDING | 93 | 98 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
|||||||||
| BINDING | 121 | 122 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
[ST]-E | ||||||||
| ACT_SITE | 126 | 126 | /note="Proton donor" | Y | ||||||||
| ACT_SITE | Cter | Cter | /note="Proton acceptor; via carboxylate" | [FY] | ||||||||
Additional information
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| Size range | 408-418 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |