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Annotation rule MF_01815
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General rule information [?]

Accession MF_01815
Dates 30-JUL-2003 (Created)
4-JUN-2021 (Last updated, Version 40)
Name FabH
Templates P0A6R0 (FABH_ECOLI); P9WNG3 (FABH_MYCTU); P68795 (FABH_STAAM); Q9F6D4 (FABH_STRLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3;
AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;
AltName: Full=Beta-ketoacyl-ACP synthase III;
Short=KAS III;
Gene name

Comments [?]

Function Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Catalytic activity RHEA:12080: acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA
Pathway Lipid metabolism; fatty acid biosynthesis.
Subunit Homodimer.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
case not <OG:Chloroplast>
Subcellular location Cytoplasm.
end case
Domain The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Similarity Belongs to the thiolase-like superfamily. FabH family.

Keywords [?]

case not <OG:Chloroplast>
end case

Gene Ontology [?]

GO:0033818; Molecular function: beta-ketoacyl-acyl-carrier-protein synthase III activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

TIGRFAMs TIGR00747; FabH; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     112     112             C  
ACT_SITE     244     244             H  
ACT_SITE     274     274             N  
REGION     245     249       ACP-binding     [QS]-[AP]-N-x-R  

Additional information [?]

Size range 309-364 amino acids
Related rules None
Fusion None