HAMAP rule MF_01815
General rule information
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Accession | MF_01815 |
Dates | 30-JUL-2003 (Created) 17-JAN-2023 (Last updated, Version 42) |
Name | FabH |
Scope | Bacteria
Plastid |
Templates | P0A6R0 (FABH_ECOLI); O34746 (FABH1_BACSU); O07600 (FABH2_BACSU); P0A3C5 (FABH_STRPN); Q54206 (FABH_STRGA); Q4URQ0 (FABH_XANC8); C0LNR0 (FABH_LISM4); P9WNG3 (FABH_MYCTU); P68795 (FABH_STAAM); Q9F6D4 (FABH_STRLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case not <OC:Mycobacterium>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Mycobacterium>
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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Function | Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. |
case not <OC:Mycobacterium>
Catalytic activity | RHEA:12080: acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA
EC 2.3.1.180 |
else case <OC:Mycobacterium>
Catalytic activity | RHEA:43640: dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA
EC 2.3.1.301 PhysiologicalDirection=left-to-right (RHEA:43641) |
end case
Pathway | Lipid metabolism; fatty acid biosynthesis. |
case <OC:Mycobacterium>
Pathway | Lipid metabolism; mycolic acid biosynthesis. |
end case
Subunit | Homodimer. |
case <OG:Chloroplast>
Subcellular location | Plastid, chloroplast. |
end case
case not <OG:Chloroplast>
Subcellular location | Cytoplasm. |
end case
Domain | The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. |
Similarity | Belongs to the thiolase-like superfamily. FabH family. |
Keywords
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case not <OG:Chloroplast>
end case
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Multifunctional enzyme
Transferase
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Multifunctional enzyme
Transferase
Gene Ontology
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GO:0033818; Molecular function: beta-ketoacyl-acyl-carrier-protein synthase III activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0006633; Biological process: fatty acid biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
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TIGRFAMs | TIGR00747; FabH; 1; |
Features
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From: FABH_ECOLI (P0A6R0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 112 | 112 | C | |||||||||
ACT_SITE | 244 | 244 | H | |||||||||
ACT_SITE | 274 | 274 | N | |||||||||
REGION | 245 | 249 | ACP-binding | [QS]-[AP]-N-x-R |
Additional information
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Size range | 309-364 amino acids |
Related rules | None |
Fusion | None |
Comments | In many organisms this enzyme can accept branched-chain acyl-CoAs (EC 2.3.1.300) in addition to acetyl-CoA. Mycobacterial enzyme acts on medium- and long-chain acyl-CoAs (EC 2.3.1.301) and has no activity with acetyl-CoA or branched-chain acyl-CoAs. |