HAMAP rule MF_01832
General rule information
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| Accession | MF_01832 |
| Dates | 30-SEP-2004 (Created)
19-NOV-2019 (Last updated, Version 17) |
| Name | SufE |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76194 (SUFE_ECOLI); Q9EXP1 (SUFE_DICD3); [ Recover all ] |
| Triggered by |
HAMAP; MF_01832 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SUFE |
| Protein name | RecName: Full=Cysteine desulfuration protein SufE; |
| Gene name | Name=sufE; |
Comments
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| FUNCTION | Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. |
| PATHWAY | Cofactor biosynthesis; iron-sulfur cluster biosynthesis. |
| SUBUNIT | Homodimer. Interacts with SufS. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the SufE family. |
Keywords
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Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF02657; SufE; 1; |
Features
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| From: SUFE_ECOLI (P76194) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 51 | 51 | /note="Cysteine persulfide intermediate" | C | ||||||||
Additional information
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| Size range | 138-144 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The suf operon encodes a minor pathway of Fe-S cluster, which is probably activated and required only in specific stressfull conditions such as oxidative stress and/or iron limitation. |